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. 1982 Feb 1;201(2):425–427. doi: 10.1042/bj2010425

Interaction of the pBR 322-coded RTEM beta-lactamase with substrates. Evidence for specific conformational transitions.

N Citri, N Zyk
PMCID: PMC1163661  PMID: 6979339

Abstract

The rate of inactivation of RTEM-1 beta-lactamase by Pronase is accelerated by class A ('resistant') penicillins. Other substrates (class S penicillin and cephalosporins) protect against the inactivation. Cefoxitin, a semi-synthetic cephamycin, induces a more extensive, hysteretic response. In its presence the enzyme is inactivated by trypsin as well as by Pronase.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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