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. 1976 Apr 15;156(1):189–192. doi: 10.1042/bj1560189

Compartmentation of albumin and ferritin synthesis in rat liver in vivo.

E B Fern, P J Garlick
PMCID: PMC1163732  PMID: 942400

Abstract

Infusion of rats with [U-14C]glycine resulted in labelling of glycine and serine in plasma albumin and liver ferritin. The patterms of labelling in these two proteins were not similar, suggesting that each is synthesized from a different pool of free amino acids.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bjorklid E., Helgeland L. Sex difference in the ferritin content of rat liver. Biochim Biophys Acta. 1970 Dec 22;221(3):583–592. doi: 10.1016/0005-2795(70)90230-8. [DOI] [PubMed] [Google Scholar]
  2. Chandrasakharam N., Fleck A., Munro H. N. Albumin content of rat hepatic cells at different levels of protein intake. J Nutr. 1967 Aug;92(4):497–502. doi: 10.1093/jn/92.4.497. [DOI] [PubMed] [Google Scholar]
  3. Cook J. D., Hershko C., Finch C. A. Storage iron kinetics. IV. Cellular distribution of ferritin iron stores in rat liver. Proc Soc Exp Biol Med. 1974 Apr;145(4):1378–1381. doi: 10.3181/00379727-145-38017. [DOI] [PubMed] [Google Scholar]
  4. Drochmans P., Wanson J. C., Mosselmans R. Isolation and subfractionation on ficoll gradients of adult rat hepatocytes. Size, morphology, and biochemical characteristics of cell fractions. J Cell Biol. 1975 Jul;66(1):1–22. doi: 10.1083/jcb.66.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Fern E. B., Garlick P. J. The specific radioactivity of the precursor pool for estimates of the rate of protein synthesis. Biochem J. 1973 Aug;134(4):1127–1130. doi: 10.1042/bj1341127. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Fern E. B., Garlick P. J. The specific radioactivity of the tissue free amino acid pool as a basis for measuring the rate of protein synthesis in the rat in vivo. Biochem J. 1974 Aug;142(2):413–419. doi: 10.1042/bj1420413. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. HAMASHIMA Y., HARTER J. G., COONS A. H. THE LOCALIZATION OF ALBUMIN AND FIBRINOGEN IN HUMAN LIVER CELLS. J Cell Biol. 1964 Feb;20:271–279. doi: 10.1083/jcb.20.2.271. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hicks S. J., Drysdale J. W., Munro H. N. Preferential synthesis of ferritin and albumin by different populations of liver polysomes. Science. 1969 May 2;164(3879):584–585. doi: 10.1126/science.164.3879.584. [DOI] [PubMed] [Google Scholar]
  9. Ilan J., Singer M. Sampling of the leucine pool from the growing peptide chain: difference in leucine specific activity of peptidyl-transfer RNA from free and membrane-bound polysomes. J Mol Biol. 1975 Jan 5;91(1):39–51. doi: 10.1016/0022-2836(75)90370-8. [DOI] [PubMed] [Google Scholar]
  10. Judah J. D., Gamble M., Steadman J. H. Biosynthesis of serum albumin in rat liver. Evidence for the existence of 'proalbumin'. Biochem J. 1973 Aug;134(4):1083–1091. doi: 10.1042/bj1341083. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Kisselev L. L., Favorova O. O. Aminoacyl-tRNA synthetases: sone recent results and achievements. Adv Enzymol Relat Areas Mol Biol. 1974;40(0):141–238. doi: 10.1002/9780470122853.ch5. [DOI] [PubMed] [Google Scholar]
  12. Konijn A. M., Baliga B. S., Munro H. N. Synthesis of liver ferritin on free and membrane-bound polyribosomes of different sizes. FEBS Lett. 1973 Dec 1;37(2):249–252. doi: 10.1016/0014-5793(73)80471-5. [DOI] [PubMed] [Google Scholar]
  13. Linder M. C., Moor J. R., Munro H. N. Subunit heterogeneity in rat liver apoferritin. Differential response of the subunits to iron administration. J Biol Chem. 1974 Dec 10;249(23):7707–7710. [PubMed] [Google Scholar]
  14. Niitsu Y., Ishitani K., Listowsky I. Subunit heterogeneity in ferritin. Biochem Biophys Res Commun. 1973 Dec 19;55(4):1134–1140. doi: 10.1016/s0006-291x(73)80013-0. [DOI] [PubMed] [Google Scholar]
  15. Puro D. G., Richter G. W. Ferritin synthesis by free and membrane-bound (poly)ribosomes of rat liver. Proc Soc Exp Biol Med. 1971 Nov;138(2):399–403. doi: 10.3181/00379727-138-35906. [DOI] [PubMed] [Google Scholar]
  16. Redman C. M. Biosynthesis of serum proteins and ferritin by free and attached ribosomes of rat liver. J Biol Chem. 1969 Aug 25;244(16):4308–4315. [PubMed] [Google Scholar]
  17. Van Wyk C. P., Linder-Horowitz M., Munro H. N. Effect of iron loading on non-heme iron compounds in different liver cell populations. J Biol Chem. 1971 Feb 25;246(4):1025–1031. [PubMed] [Google Scholar]

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