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. 1976 Jul 1;157(1):267–270. doi: 10.1042/bj1570267

Types I and II collagens in intervertebral disc. Interchanging radial distributions in annulus fibrosus.

D R Eyre, H Muir
PMCID: PMC1163842  PMID: 962859

Abstract

Intervertebral disc is a highly specialized cartilaginous tissue, containing two genetic types of collagen (I and II). Analysis of peptides from a CNBr digest of collagen showed that the proportions of I and II varied gradually and inversely across pig annulus fibrosus, with exclusively type I at the extreme outer edge and exclusively type II in the nucleus pulposus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Eyre D. R., Glimcher M. J. Collagen cross-linking. Isolation of cross-linked peptides from collagen of chicken bone. Biochem J. 1973 Nov;135(3):393–403. doi: 10.1042/bj1350393. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Eyre D. R., Muir H. Collagen polymorphism: two molecular species in pig intervertebral disc. FEBS Lett. 1974 Jun 1;42(2):192–196. doi: 10.1016/0014-5793(74)80783-0. [DOI] [PubMed] [Google Scholar]
  3. Eyre D. R., Muir H. The distribution of different molecular species of collagen in fibrous, elastic and hyaline cartilages of the pig. Biochem J. 1975 Dec;151(3):595–602. doi: 10.1042/bj1510595. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Furthmayr H., Timpl R. Characterization of collagen peptides by sodium dodecylsulfate-polyacrylamide electrophoresis. Anal Biochem. 1971 Jun;41(2):510–516. doi: 10.1016/0003-2697(71)90173-4. [DOI] [PubMed] [Google Scholar]
  5. Gallop P. M., Paz M. A. Posttranslational protein modifications, with special attention to collagen and elastin. Physiol Rev. 1975 Jul;55(3):418–487. doi: 10.1152/physrev.1975.55.3.418. [DOI] [PubMed] [Google Scholar]
  6. Habuchi H., Yamagata T., Iwata H., Suzuki S. The occurrence of a wide variety of dermatan sulfate-chondroitin sulfate copolymers in fibrous cartilage. J Biol Chem. 1973 Sep 10;248(17):6019–6028. [PubMed] [Google Scholar]
  7. Hahn E., Timpl R., Miller E. J. The production of specific antibodies to native collagens with the chain compositions, (alpha1(I))3, (alpha1(II))3, and (alpha1(I))2alpha 2. J Immunol. 1974 Jul;113(1):421–423. [PubMed] [Google Scholar]
  8. Miller E. J., Matukas V. J. Biosynthesis of collagen. The biochemist's view. Fed Proc. 1974 May;33(5):1197–1204. [PubMed] [Google Scholar]
  9. Nimni M. E. Collagen: Its structure and function in normal and pathological connective tissues. Semin Arthritis Rheum. 1974 Winter;4(2):95–150. doi: 10.1016/0049-0172(74)90001-8. [DOI] [PubMed] [Google Scholar]

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