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. 1976 Aug 15;158(2):509–512. doi: 10.1042/bj1580509

3-oxo acid coenzyme A-transferase in normal and diabetic rat muscle.

A Fenselau, K Wallis
PMCID: PMC1163999  PMID: 136250

Abstract

The amounts of succinyl-CoA--3-oxo acid CoA-transferase (EC 2.8.3.5) decrease progressively in skeletal muscle in streptozotocin-diabetic rats, reaching after 10 days about 50% of the value in normal rat muscle. Electrofocusing studies indicate the occurrence of partial proteolysis of the enzyme in diabetic muscle. However, several functional parameters relating to acetoacetate utilization, including substrate inhibition, are quite similar for muscle transferase preparations from normal and diseased rats. The development of pathological ketoacidosis is discussed in the light of these observations.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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