Figure 5. Exacerbated DG GC activation in ΔCTD GluA1 mice following open field exposure.

A: Schematic of open field experiment. c-Fos expression was analyzed in several brain regions after two hours in the open field arena in WT and ΔCTD GluA1 mice. B: representative c-Fos staining (red) in WT and ΔCTD GluA1 hippocampus. C-E: Average number of c-Fos-positive cells in the dentate gyrus granule layer, CA3, and CA1, respectively. Error bars represent SEM. Empty dots represent females, filled dots represent males. Scale bar: 200 μm. **, p≤0.01; ***, p≤0.001; ****, p≤0.0001, one-way ANOVA.