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[Preprint]. 2024 Dec 4:2024.12.03.626601. [Version 1] doi: 10.1101/2024.12.03.626601

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Figure 1. — a. Analysis of acquired cysteines within 680 human E3 ligases. b. The TCGA hotspot count of the 39 acquired cysteines occurring in 35 E3 ligases. c. Screening of an FKBP12-directed heterobifunctional compound library to identify compounds that degrade FKBP12 in an FBXW7-R465C-dependent manner.