In the original publication [1], there was a mistake in Table 5 as published. During the proofreading stage, Table 5 was accidentally duplicated with Table 6. The corrected Table 5 appears below.
Table 5.
Main affected pathways in Gene Ontology (GO) in rats exposed by instillation to SiO2_15_Unmod and SiO2_15_Amino.
| NM | Exposure Condition | Rank | Id | Size | p Value | Description |
|---|---|---|---|---|---|---|
| SiO2_15_Unmod | Exposure Group | 1 | GO:0007127 | 83 (112) | 6.00 × 10−7 | meiosis I |
| 2 | GO:0048247 | 42 (46) | 3.50 × 10−6 | lymphocyte chemotaxis | ||
| 3 | GO:0071459 | 15 (21) | 5.20 × 10−6 | protein localization to chromosome, centromeric | ||
| 4 | GO:0060340 | 10 (11) | 8.20 × 10−6 | positive regulation of type I interferon-mediated | ||
| 5 | GO:0070098 | 63 (66) | 1.30 × 10−5 | chemokine-mediated signaling pathway | ||
| 6 | GO:0072676 | 73 (78) | 2.00 × 10−5 | lymphocyte migration | ||
| 7 | GO:0045132 | 67 (93) | 3.20 × 10−5 | meiotic chromosome segregation | ||
| 8 | GO:0034501 | 13 (18) | 4.20 × 10−5 | protein localization to kinetochore | ||
| 9 | GO:0034502 | 64 (76) | 1.80 × 10−4 | protein localization to chromosome | ||
| 10 | GO:0070192 | 53 (72) | 1.90 × 10−4 | chromosome organization involved in meiotic cell cycle | ||
| Recovery Group | 1 | GO:0048680 | 9 (11) | 2.20 × 10−5 | positive regulation of axon regeneration | |
| 2 | GO:0070572 | 10 (12) | 8.80 × 10−5 | positive regulation of neuron projection | ||
| 3 | GO:2001223 | 10 (11) | 1.60 × 10−4 | negative regulation of neuron migration | ||
| 4 | GO:2000849 | 11 (11) | 1.60 × 10−4 | regulation of glucocorticoid secretion | ||
| 5 | GO:0071300 | 65 (76) | 3.30 × 10−4 | cellular response to retinoic acid | ||
| 6 | GO:0003348 | 6 (6) | 3.60 × 10−4 | cardiac endothelial cell differentiation | ||
| 7 | GO:0060956 | 6 (6) | 3.60 × 10−4 | endocardial cell differentiation | ||
| 8 | GO:0006297 | 5 (5) | 3.70 × 10−4 | nucleotide-excision repair, DNA gap filling | ||
| 9 | GO:0035933 | 12 (12) | 5.10 × 10−4 | glucocorticoid secretion | ||
| 10 | GO:2000852 | 5 (5) | 5.50 × 10−4 | regulation of corticosterone secretion | ||
| SiO2_15_Amino | Exposure Group | 1 | GO:0000910 | 96 (110) | 1.50 × 10−7 | cytokinesis |
| 2 | GO:0000281 | 42 (47) | 4.00 × 10−7 | mitotic cytokinesis | ||
| 3 | GO:0033260 | 23 (30) | 5.40 × 10−6 | nuclear DNA replication | ||
| 4 | GO:0071459 | 15 (21) | 7.60 × 10−6 | protein localization to chromosome, centromeric | ||
| 5 | GO:0051383 | 12 (14) | 1.80 × 10−5 | kinetochore organization | ||
| 6 | GO:0051414 | 7 (7) | 2.00 × 10−5 | response to cortisol | ||
| 7 | GO:0040020 | 31 (35) | 2.30 × 10−5 | regulation of meiotic nuclear division | ||
| 8 | GO:0061640 | 49 (56) | 2.50 × 10−5 | cytoskeleton-dependent cytokinesis | ||
| 9 | GO:0051445 | 45 (51) | 2.50 × 10−5 | regulation of meiotic cell cycle | ||
| 10 | GO:1902969 | 9 (10) | 3.90 × 10−5 | mitotic DNA replication | ||
| Recovery Group | 1 | GO:0035082 | 44 (60) | 1.90 × 10−14 | axoneme assembly | |
| 2 | GO:0003341 | 44 (64) | 7.10 × 10−13 | cilium movement | ||
| 3 | GO:0001578 | 66 (89) | 4.80 × 10−8 | microtubule bundle formation | ||
| 4 | GO:0002385 | 25 (39) | 2.60 × 10−5 | mucosal immune response | ||
| 5 | GO:0060294 | 15 (17) | 3.50 × 10−5 | cilium movement involved in cell motility | ||
| 6 | GO:0030199 | 38 (44) | 5.10 × 10−5 | collagen fibril organization | ||
| 7 | GO:0001539 | 19 (22) | 5.20 × 10−5 | cilium or flagellum-dependent cell motility | ||
| 8 | GO:0060285 | 19 (22) | 5.20 × 10−5 | cilium-dependent cell motility | ||
| 9 | GO:0002251 | 26 (40) | 5.20 × 10−5 | organ or tissue specific immune response | ||
| 10 | GO:0048755 | 13 (13) | 6.50 × 10−5 | branching morphogenesis of a nerve |
Rats were exposed by instillation to 0.36 mg of SiO2_15_Unmod or SiO2_15_Amino and euthanized to isolate total RNA from the lungs both at 3 days (Exposure group; E) and 21 days (Recovery group; R) after initial instillation.
The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.
Footnotes
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Reference
- 1.Brandão F., Costa C., Bessa M.J., Dumortier E., Debacq-Chainiaux F., Hubaux R., Salmon M., Laloy J., Stan M.S., Hermenean A., et al. Genotoxicity and Gene Expression in the Rat Lung Tissue following Instillation and Inhalation of Different Variants of Amorphous Silica Nanomaterials (aSiO2 NM) Nanomaterials. 2021;11:1502. doi: 10.3390/nano11061502. [DOI] [PMC free article] [PubMed] [Google Scholar]