Figure 3.

The effects of B. leptopoda extracts (FE and AE) on cell cycle regulatory proteins and FGF7 expression in hypertrophic scar fibroblasts. (A) BrdU absorbance levels indicate the reduction in TGF-β1-induced cell proliferation after treatment with FE and AE extracts. (B) FGF7 expression analysis revealed no significant differences between the experimental and control groups. (C,D) Inhibition of Cyclin A and B1 expression by FE and AE, demonstrating their regulatory effects on DNA replication and mitosis. (E,F) Upregulation of CDK2 levels, indicating increased fibroblast entry into the DNA synthesis phase. The experimental results were repeated three times, and all were expressed in the form of mean ± standard deviation (SD). Different letters indicate significant differences (p < 0.05).