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. 1977 Jan 15;162(1):195–197. doi: 10.1042/bj1620195

Collagenase is a component of the specific granules of human neutrophil leucocytes.

G Murphy, J J Reynolds, U Bretz, M Baggiolini
PMCID: PMC1164583  PMID: 192209

Abstract

Azurophil and specific granules were isolated from human polymorphonuclear neutrophil leucocytes. Collagenase was almost exclusively a component of the specific granules. This finding is in contrast with the distribution of other proteolytic enzymes, which are localized in the azurophil (or lysosomal) granules.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baggiolini M. The isolation of granules from neutrophile polymorphonuclear leukocytes (PMN's). Methods Enzymol. 1974;31:345–353. doi: 10.1016/0076-6879(74)31037-3. [DOI] [PubMed] [Google Scholar]
  2. Bainton D. F. Sequential degranulation of the two types of polymorphonuclear leukocyte granules during phagocytosis of microorganisms. J Cell Biol. 1973 Aug;58(2):249–264. doi: 10.1083/jcb.58.2.249. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bainton D. F., Ullyot J. L., Farquhar M. G. The development of neutrophilic polymorphonuclear leukocytes in human bone marrow. J Exp Med. 1971 Oct 1;134(4):907–934. doi: 10.1084/jem.134.4.907. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bretz U., Baggiolini M. Biochemical and morphological characterization of azurophil and specific granules of human neutrophilic polymorphonuclear leukocytes. J Cell Biol. 1974 Oct;63(1):251–269. doi: 10.1083/jcb.63.1.251. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Dewald B., Rindler-Ludwig R., Bretz U., Baggiolini M. Subcellular localization and heterogeneity of neutral proteases in neutrophilic polymorphonuclear leukocytes. J Exp Med. 1975 Apr 1;141(4):709–723. doi: 10.1084/jem.141.4.709. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Harris E. D., Jr, Krane S. M. Collagenases (first of three parts). N Engl J Med. 1974 Sep 12;291(11):557–563. doi: 10.1056/NEJM197409122911105. [DOI] [PubMed] [Google Scholar]
  7. Harris E. D., Jr, Krane S. M. Collagenases (second of three parts). N Engl J Med. 1974 Sep 19;291(12):605–609. doi: 10.1056/NEJM197409192911205. [DOI] [PubMed] [Google Scholar]
  8. Harris E. D., Jr, Krane S. M. Collagenases (third of three parts). N Engl J Med. 1974 Sep 26;291(13):652–661. doi: 10.1056/NEJM197409262911305. [DOI] [PubMed] [Google Scholar]
  9. Hoffstein S., Soberman R., Goldstein I., Weissmann G. Concanavalin A induces microtubule assembly and specific granule discharge in human polymorphonuclear leukocytes. J Cell Biol. 1976 Mar;68(3):781–787. doi: 10.1083/jcb.68.3.781. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Jeffrey J. J., Gross J. Collagenase from rat uterus. Isolation and partial characterization. Biochemistry. 1970 Jan 20;9(2):268–273. doi: 10.1021/bi00804a012. [DOI] [PubMed] [Google Scholar]
  11. Kruze D., Wojtecka E. Activation of leucocyte collagenase proenzyme by rheumatoid synovial fluid. Biochim Biophys Acta. 1972 Dec 28;285(2):436–446. doi: 10.1016/0005-2795(72)90330-3. [DOI] [PubMed] [Google Scholar]
  12. Lazarus G. S., Brown R. S., Daniels J. R., Fullmer H. M. Human granulocyte collagenase. Science. 1968 Mar 29;159(3822):1483–1485. doi: 10.1126/science.159.3822.1483. [DOI] [PubMed] [Google Scholar]
  13. Lazarus G. S., Daniels J. R., Lian J., Burleigh M. C. Role of granulocyte collagenase in collagen degradation. Am J Pathol. 1972 Sep;68(3):565–578. [PMC free article] [PubMed] [Google Scholar]
  14. Leffell M. S., Spitznagel J. K. Association of lactoferrin with lysozyme in granules of human polymorphonuclear leukocytes. Infect Immun. 1972 Nov;6(5):761–765. doi: 10.1128/iai.6.5.761-765.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Ohlsson K., Olsson I. The neutral proteases of human granulocytes. Isolation and partial characterization of two granulocyte collagenases. Eur J Biochem. 1973 Jul 16;36(2):473–481. doi: 10.1111/j.1432-1033.1973.tb02932.x. [DOI] [PubMed] [Google Scholar]
  16. Oronsky A. L., Perper R. J., Schroder H. C. Phagocytic release and activation of human leukocyte procollagenase. Nature. 1973 Dec 14;246(5433):417–419. doi: 10.1038/246417a0. [DOI] [PubMed] [Google Scholar]
  17. Robertson P. B., Ryel R. B., Taylor R. E., Shyu K. W., Fullmer H. M. Collagenase: localization in polymorphonuclear leukocyte granules in the rabbit. Science. 1972 Jul 7;177(4043):64–65. doi: 10.1126/science.177.4043.64. [DOI] [PubMed] [Google Scholar]
  18. Weissmann G., Goldstein I., Hoffstein S., Chauvet G., Robineaux R. Yin/Yang modulation of lysosomal enzyme release from polymorphonuclear leukocytes by cyclic nucleotides. Ann N Y Acad Sci. 1975 Jun 13;256:222–232. doi: 10.1111/j.1749-6632.1975.tb36049.x. [DOI] [PubMed] [Google Scholar]
  19. Werb Z., Burleigh M. C. A specific collagenase from rabbit fibroblasts in monolayer culture. Biochem J. 1974 Feb;137(2):373–385. doi: 10.1042/bj1370373. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Werb Z., Reynolds J. J. Purification and properties of a specific collagenase from rabbit synovial fibroblasts. Biochem J. 1975 Dec;151(3):645–653. doi: 10.1042/bj1510645. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Woolley D. E., Tucker J. S., Green G., Evanson J. M. A neutral collagenase from human gastric mucosa. Biochem J. 1976 Jan 1;153(1):119–126. doi: 10.1042/bj1530119. [DOI] [PMC free article] [PubMed] [Google Scholar]

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