Skip to main content
PMC home page
Biochemical Journal logoLink to Biochemical Journal
. 1977 Mar 15;162(3):493–499. doi: 10.1042/bj1620493

Nature of the stimulation of biogenesis of cholesterol in the liver by noradrenaline.

R George, T Ramasarma
PMCID: PMC1164632  PMID: 68775

Abstract

1. Administration of noradrenaline increased the incorporation of [1-14C]acetate into hepatic sterols and the activity of liver microsomal 3-hydroxy-3-methylglutaryl-CoA reductase. 2. The stimulation was observed at short time-intervals with a maximum at 4h and was progressive with increasing concentrations of noradrenaline. 3. Protein synthesis de novo was a necessary factor for the effect. 4. The stimulatory effect was not mediated through the adrenergic receptors, but appears to involve a direct action of the hormone within the hepatocyte.

Full text

PDF
493

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bortz W. M. Noradrenalin-induced increase in hepatic cholesterol synthesis and its blockade by puromycin. Biochim Biophys Acta. 1968 May 1;152(3):619–626. doi: 10.1016/0005-2760(68)90102-1. [DOI] [PubMed] [Google Scholar]
  2. Bortz W. M. On the control of cholesterol synthesis. Metabolism. 1973 Dec;22(12):1507–1524. doi: 10.1016/0026-0495(73)90019-x. [DOI] [PubMed] [Google Scholar]
  3. Bricker L. A., Levey G. S. Evidence for regulatin of cholesterol and fatty acid synthesis in liver by cyclic adenosine 3',5'-monophosphate. J Biol Chem. 1972 Aug 10;247(15):4914–4915. [PubMed] [Google Scholar]
  4. Dairman W., Christenson J. G., Udenfriend S. Changes in tyrosine hydroxylase and dopa decarboxylase induced by pharmacological agents. Pharmacol Rev. 1972 Jun;24(2):269–289. [PubMed] [Google Scholar]
  5. De Matteis F. Stimulation of liver cholesterol synthesis by actinomycin D. Biochem J. 1968 Oct;109(5):775–785. doi: 10.1042/bj1090775. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Edwards P. A. Effect of adrenalectomy and hypophysectomy on the circadian rhythm of -hydroxy- -methylglutaryl coenzyme A reductase activity in rat liver. J Biol Chem. 1973 Apr 25;248(8):2912–2917. [PubMed] [Google Scholar]
  7. Edwards P. A. The influence of catecholamines and cyclic AMP on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and lipid biosynthesis in isolated rat hepatocytes. Arch Biochem Biophys. 1975 Sep;170(1):188–203. doi: 10.1016/0003-9861(75)90110-1. [DOI] [PubMed] [Google Scholar]
  8. Hellerman L., Erwin V. G. Mitochondrial monoamine oxidase. II. Action of various inhibitors for the bovine kidney enzyme. Catalytic mechanism. J Biol Chem. 1968 Oct 25;243(20):5234–5243. [PubMed] [Google Scholar]
  9. Hornbrook K. R. Adrenergic receptors for metabolic responses in the liver. Fed Proc. 1970 Jul-Aug;29(4):1381–1385. [PubMed] [Google Scholar]
  10. Huber J., Guder W., Latzin S., Hamprecht B. The influence of insulin and glucagon on hydroxymethylglutaryl coenzyme A reductase activity in rat liver. Hoppe Seylers Z Physiol Chem. 1973 Jul;354(7):795–798. [PubMed] [Google Scholar]
  11. Louw A. I., Bekersky I., Mosbach E. H. Improved synthesis of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). J Lipid Res. 1969 Nov;10(6):683–686. [PubMed] [Google Scholar]
  12. Nepokroeff C. M., Lakshmanan M. R., Ness G. C., Dugan R. E., Porter J. W. Regulation of the diurnal rhythm of rat liver beta-hydroxy-beta-methylglutaryl coenzmye A reductase activity by insulin, glucagon, cyclic AMP and hydrocortisone. Arch Biochem Biophys. 1974 Feb;160(2):387–396. doi: 10.1016/0003-9861(74)90412-3. [DOI] [PubMed] [Google Scholar]
  13. Ness G. C., Dugan R. E., Lakshmanan M. R., Nepokroeff C. M., Porter J. W. Stimulation of hepatic beta-hydroxy-beta-methylglutaryl coenzyme A reductase activity in hypophysectomized rats by L-triiodothyronine. Proc Natl Acad Sci U S A. 1973 Dec;70(12):3839–3842. doi: 10.1073/pnas.70.12.3839. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Rao G. S., George R., Ramasarma T. Stimulation of hepatic biogenesis of sterols on administration of adenosine compounds. Biochem J. 1976 Mar 15;154(3):639–645. doi: 10.1042/bj1540639. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Saitoh Y., Ui M. Stimulation of glycogenolysis and gluconeogenesis by epinephrine independent of its beta-adrenergic function in perfused rat liver. Biochem Pharmacol. 1976 Apr 1;25(7):841–845. doi: 10.1016/0006-2952(76)90156-8. [DOI] [PubMed] [Google Scholar]
  16. Shapiro D. J., Nordstrom J. L., Mitschelen J. J., Rodwell V. W., Schimke R. T. Micro assay for 3-hydroxy-3-methylglutaryl-CoA reductase in rat liver and in L-cell fibroblasts. Biochim Biophys Acta. 1974 Dec 29;370(2):369–377. doi: 10.1016/0005-2744(74)90098-9. [DOI] [PubMed] [Google Scholar]
  17. Shapiro D. J., Rodwell V. W. Regulation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol synthesis. J Biol Chem. 1971 May 25;246(10):3210–3216. [PubMed] [Google Scholar]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society

RESOURCES