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. 1977 May 15;164(2):461–464. doi: 10.1042/bj1640461

Enhanced plasma persistence of therapeutic enzymes by coupling to soluble dextran.

R F Sherwood, J K Baird, T Atkinson, C N Wiblin, D A Rutter, D C Ellwood
PMCID: PMC1164813  PMID: 880251

Abstract

Conjugation of carboxypeptidase G and arginase, two enzymes of therapeutic interest, to a soluble dextran significantly enhanced plasma persistence in normal and tumour-bearing mice. A prolonged decrease in arginine concentrations in plasma of tumour-bearing mice was demonstrated by using the dextran-linked arginase. Gel filtration of dextran-enzyme conjugate showed that enzyme activity co-chromatographed as a single peak with carbohydrate, and enzyme was shown to be covalently linked to the dextran.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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