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. 1977 Jun 15;164(3):617–620. doi: 10.1042/bj1640617

The probable site of action of thenolytrifluoracetone on the respiratory chain.

W J Ingledew, T Ohnishi
PMCID: PMC1164839  PMID: 196591

Abstract

1. It is shown that the electron-transfer inhibitor thenoyltrifluoroacetone abolishes a respiratory-chain electron-paramagnetic-resonance absorbance due to spin-spin interactions of ubisemiquinones at concentrations similar to those required for inhibition of succinate oxidation. 2. A specific site of interaction of thenoyltrifluoroacetone with the respiratory chain is proposed to be on the ubisemiquinone with which succinate dehydrogenase reacts. 3. Our results further demonstrate the close association of the HiPIP (high-potential iron-sulphur) centre of succinate dehydrogenase with ubisemiquinone.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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