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Frontiers in Oncology logoLink to Frontiers in Oncology
. 2024 Dec 2;14:1513956. doi: 10.3389/fonc.2024.1513956

Corrigendum: Exogenous let-7a-5p induces A549 lung cancer cell death through BCL2L1-mediated PI3Kγ signaling pathway

Shuyin Duan 1,2, Songcheng Yu 2, Teng Yuan 3, Sanqiao Yao 4,*, Lin Zhang 1,5,*
PMCID: PMC11648416  PMID: 39687894

In the published article, errors appeared in Figures 3B, C, 4E, F, and 7A, B. During the transwell assay and scratch test procedures, we used the equipment’s default image naming system for batch exports, which led to difficulties in distinguishing between intervention groups during image selection and resulted in incorrect image placement. Given that a significant amount of time has elapsed since publication, the original data associated with these results are no longer available. We therefore carried out independent repeat experiments and achieved outcomes consistent with the initial findings. As a result, the relevant images and their quantitative data in Figures 3B–E, 4E–H, and 7A, B have been updated.

Figure 3.

Figure 3

Aberrant expression of let-7a-5p alters the growth, migration, and invasion of A459 lung cancer cells. (A) CCK8 assays show that let-7a-5p suppresses the growth of A549 lung cancer cells. (B, C) Transwell assays demonstrate that let-7a-5p inhibits the invasion (B) and migration (C) of A549 lung cancer cells. (D, E) Quantitative analysis of (B, C). NC represents the negative control. * p < 0.05 compared with the control group, using the pooled variance t-test.

Figure 4.

Figure 4

BCL2L1 modulates the migration and invasion of A549 lung cancer cells. (A) Examination of the knockdown efficiency of the sh-BCL2L1 plasmid using RT-qPCR. (B) RT-qPCR assays of BCL2L1 in A459 lung cancer cells transfected with pc-BCL2L1 or negative control. (C, D) Western blot gels and protein expression analysis of BCL2L1 in A459 lung cancer cells transfected with shRNAs or pcDNAs. (E, F), Transwell assays show the alterations of cell invasion (E) and migration (F) of A459 lung cancer cells. (G, H) Quantitative analysis of (E, F). NC, negative control. * p < 0.05 compared with the control group using the pooled variance t test.

Figure 7.

Figure 7

Effect of let-7a-5p-BCL2L1 crosstalk on lung cancer cells in vitro. (A) Wound healing assays exhibit the effect of let-7a-5p-BCL2L1 crosstalk on the migration of A459 lung cancer cells. (B) Quantitative analysis of (A). (C–F) RT-qPCR analysis of lung cancer biomarkers. let-7, let-7a-5p; NC, negative control. * p < 0.05 compared with the indicated group, using the pooled variance t-test.

The corrected Figure 3 and its caption are provided below.

The corrected Figure 4 and its caption are provided below.

The corrected Figure 7 and its caption are provided below.

The authors apologize for these errors and confirm that this does not change the scientific conclusions of the. The original article has been updated.

Publisher’s note

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