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. 1977 Aug 1;165(2):409–411. doi: 10.1042/bj1650409

Aldolase-like imine formation in the mechanism of action of phosphonoacetaldehyde hydrolase.

J M La Nauze, J R Coggins, H B Dixon
PMCID: PMC1164914  PMID: 200222

Abstract

Phosphonoacetaldehyde hydrolase (EC 3.11.1.1), the bacterial enzyme that catalyses the reaction HCO-CH2-PO(OH)2+H2O leads to HCO-CH3+Pi, is inactivated by borohydride if either phosphonoacetaldehyde or acetaldehyde is present. This supports the suggestion that the substrate forms an imine with an amino group of the enzyme. Such imine formation would labilize the C-P bond in the same way that aldolase and related enzymes labilize C-C and C-H bonds (Scheme 1a).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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