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. 1977 Sep 15;166(3):415–420. doi: 10.1042/bj1660415

Differential repression of arylsulphatase synthesis in Aspergillus oryzae.

G R Burns, C H Wynn
PMCID: PMC1165024  PMID: 597236

Abstract

1. The activities of the three arylsulphatases (arylsulphate sulphohydrolase, EC 3.1.6.1) of Aspergillus oryzae produced under a variety of repressing and non-repressing conditions were determined. 2. These enzymes exhibit different sensitivities to repression by inorganic sulphate. 3. Arylsulphatase I, but not arylsulphatases II and III, exhibits a transient de-repression in the early growth phase in sulphate media. 4. When the fungus is cultured in repressing media and subsequently transferred to non-repressing media, the synthesis of the three enzymes is non-co-ordinate. 5. Growth of the fungus in media containing choline O-sulphate or tyrosine O-sulphate as the sole source of sulphur results in complete de-repression of arylsulphatase I, But the synthesis of arylsulphatases II and III is essentially fully repressed. 6. The marked similarities between the repression characteristics of arylsulphatases II and III, contrasted with those of arylsulphatase I, indicate that the genetic locus of arylsulphatase I is distinct from that of arylsulphatases II and III, suggesting that there are distinct physiological roles for the enzyme.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Apte B. N., Bhavsar P. N., Siddiqi O. The regulation of aryl sulphatase in Aspergillus nidulans. J Mol Biol. 1974 Jul 5;86(3):637–648. doi: 10.1016/0022-2836(74)90186-7. [DOI] [PubMed] [Google Scholar]
  2. Bellenger N., Nissen P., Wood T. C., Segel I. H. Specificity and control of choline-O-sulfate transport in filamentous fungi. J Bacteriol. 1968 Nov;96(5):1574–1585. doi: 10.1128/jb.96.5.1574-1585.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Burns G. R., Wynn C. H. Studies on the Arylsulphatase and phenol sulphotransferase activities of Aspergillus oryzae. Biochem J. 1975 Sep;149(3):697–705. doi: 10.1042/bj1490697. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. DODGSON K. S., ROSE F. A., TUDBALL N. Studies on sulphatases. 23. The enzymic desulphation of tyrosine O-sulphate. Biochem J. 1959 Jan;71(1):10–15. doi: 10.1042/bj0710010. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Fitzgerald J. W., Payne W. J. The regulation of arylsulphatase formation in Pseudomonas C 12 B. Microbios. 1972 Sep-Oct;6(22):147–156. [PubMed] [Google Scholar]
  6. HARADA T., SPENCER B. The effect of sulphate assimilation on the induction of arylsulphatase synthesis in fungi. Biochem J. 1962 Jan;82:148–156. doi: 10.1042/bj0820148. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Jerfy A., Roy A. B. The sulphatase of ox liver. XVI. A comparison of the arylsulphatase and cerebroside sulphatase activities of sulphatase A. Biochim Biophys Acta. 1973 Jan 12;293(1):178–190. doi: 10.1016/0005-2744(73)90389-6. [DOI] [PubMed] [Google Scholar]
  8. Marzluf G. A. Genetic and biochemical studies of distinct sulfate permease species in different developmental stages of Neurospora crassa. Arch Biochem Biophys. 1970 May;138(1):254–263. doi: 10.1016/0003-9861(70)90306-1. [DOI] [PubMed] [Google Scholar]
  9. Matalon R., Arbogast B., Dorfman A. Deficiency of chondroitin sulfate N-acetylgalactosamine 4-sulfate sulfatase in Maroteaux-Lamy syndrome. Biochem Biophys Res Commun. 1974 Dec 23;61(4):1450–1457. doi: 10.1016/s0006-291x(74)80446-8. [DOI] [PubMed] [Google Scholar]
  10. McGuire W. G., Marzluf G. A. Developmental regulation of choline sulfatase and aryl sulfatase in Neurospora crassa. Arch Biochem Biophys. 1974 Apr 2;161(2):360–368. doi: 10.1016/0003-9861(74)90316-6. [DOI] [PubMed] [Google Scholar]
  11. McGuire W. G., Marzluf G. A. Sulfur storage in Neurospora: soluble sulfur pools of several developmental stages. Arch Biochem Biophys. 1974 Apr 2;161(2):570–580. doi: 10.1016/0003-9861(74)90340-3. [DOI] [PubMed] [Google Scholar]
  12. O'Brien J. F., Cantz M., Spranger J. Maroteaux-Lamy disease (mucopolysaccharidosis VI), subtype A: deficiency of a N-acetylgalactosamine-4-sulfatase. Biochem Biophys Res Commun. 1974 Oct 8;60(3):1170–1177. doi: 10.1016/0006-291x(74)90435-5. [DOI] [PubMed] [Google Scholar]
  13. Schmit J. C., Brody S. Biochemical genetics of Neurospora crassa conidial germination. Bacteriol Rev. 1976 Mar;40(1):1–41. doi: 10.1128/br.40.1.1-41.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Spencer B., Harada T. The role of choline sulphate in the sulphur metabolism of fungi. Biochem J. 1960 Nov;77(2):305–315. doi: 10.1042/bj0770305. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Stinshoff K., Jatzkewitz H. Comparison of the cerebroside sulphatase and the arylsulphatase activity of human sulphatase A in the absence of activators. Biochim Biophys Acta. 1975 Jan 23;377(1):126–138. doi: 10.1016/0005-2744(75)90293-4. [DOI] [PubMed] [Google Scholar]

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