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. 1977 Sep 15;166(3):635–637. doi: 10.1042/bj1660635

The effect of 1,4-diaminobutanone on the stability of ornithine decarboxylase from Aspergillus nidulans.

L Stevens, I M McKinnon
PMCID: PMC1165050  PMID: 339910

Abstract

1,4-Diaminobutanone, a competitive inhibitor of ornithine decarboxylase in Aspergillus nidulans, is able to increase the half-life of this enzyme and thus stimulate an increase in its activity in vivo. It also protects ornithine decarboxylase against proteolysis by chymotrypsin in vitro.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Clark J. L. Specific induction of ornithine decarboxylase in 3T3 mouse fibroblasts by pituitary growth factors: cell density-dependent biphasic response and alteration of half-life. Biochemistry. 1974 Oct 22;13(22):4668–4674. doi: 10.1021/bi00719a031. [DOI] [PubMed] [Google Scholar]
  2. Hölttä E. Immunochemical demonstration of increased accumulation of ornithine carboxylase in rat liver after partial hepatectomy and growth hormone induction. Biochim Biophys Acta. 1975 Aug 13;399(2):420–427. doi: 10.1016/0304-4165(75)90270-6. [DOI] [PubMed] [Google Scholar]
  3. Jänne J., Hölttä E., Guha S. K. Polyamines in mammalian liver during growth and development. Prog Liver Dis. 1976;5:100–124. [PubMed] [Google Scholar]
  4. Kay J. E., Lindsay V. J. Polyamine synthesis during lymphocyte activation. Induction of ornithine decarboxylase and S-adenosyl methionine decarboxylase. Exp Cell Res. 1973 Mar 15;77(1):428–436. doi: 10.1016/0014-4827(73)90597-1. [DOI] [PubMed] [Google Scholar]
  5. Morris D. R., Fillingame R. H. Regulation of amino acid decarboxylation. Annu Rev Biochem. 1974;43(0):303–325. doi: 10.1146/annurev.bi.43.070174.001511. [DOI] [PubMed] [Google Scholar]
  6. Raina A., Jänne J. Physiology of the natural polyamines putrescine, spermidine and spermine. Med Biol. 1975 Jun;53(3):121–147. [PubMed] [Google Scholar]
  7. Russell D. H., Snyder S. H. Amine synthesis in regenerating rat liver: extremely rapid turnover of ornithine decarboxylase. Mol Pharmacol. 1969 May;5(3):253–262. [PubMed] [Google Scholar]
  8. Stevens L., McKinnon I. M., Winther M. Polyamine and ornithine metabolism during the germination of conidia of Aspergillus nidulans. Biochem J. 1976 Aug 15;158(2):235–241. doi: 10.1042/bj1580235. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Stevens L., McKinnon I. M., Winther M. The effects of 1,4-diaminobutanone on polyamine synthesis in Aspergillus nidulans. FEBS Lett. 1977 Mar 15;75(1):180–182. doi: 10.1016/0014-5793(77)80081-1. [DOI] [PubMed] [Google Scholar]
  10. Stevens L. Ornithine decarboxylase activity in germinating conidia of Aspergillus nidulans. FEBS Lett. 1975 Nov 1;59(1):80–82. doi: 10.1016/0014-5793(75)80345-0. [DOI] [PubMed] [Google Scholar]
  11. Tabor C. W., Tabor H. 1,4-Diaminobutane (putrescine), spermidine, and spermine. Annu Rev Biochem. 1976;45:285–306. doi: 10.1146/annurev.bi.45.070176.001441. [DOI] [PubMed] [Google Scholar]
  12. Williams-Ashman H. G., Jänne J., Coppoc G. L., Geroch M. E., Schenone A. New aspects of polyamine biosynthesis in eukaryotic organisms. Adv Enzyme Regul. 1972;10:225–245. doi: 10.1016/0065-2571(72)90016-7. [DOI] [PubMed] [Google Scholar]

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