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. 1975 Mar;145(3):475–482. doi: 10.1042/bj1450475

Phosphotriesters in rat liver deoxyribonucleic acid after the administration of the carcinogen NN-dimethylnitrosamine in vivo.

P J O'Connor, G P Marigison, A W Craig
PMCID: PMC1165247  PMID: 168868

Abstract

After treatment with NN-di[14C]methylnitrosamine, samples of DNA were isolated from rat livers by a conventional phenol procedure and examined for the presence of phosphotriesters. A method of capable of detecting relatively small amounts of 14C-labelled phosphotriesters was developed and used to establish that these products account for 10-12% of the total methylation pattern found after treatment with this agent in vitro. The significance of the presence of phosphotriesters in DNA is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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