Skip to main content
PMC home page
Biochemical Journal logoLink to Biochemical Journal
. 1975 Jan;146(1):273–275. doi: 10.1042/bj1460273

Aerobic lactate production by mammary tissue.

A R Elkin, N J Kuhn
PMCID: PMC1165297  PMID: 1147900

Abstract

Glucose uptake and L-lactate production were measured in cell, slice and intact tissue preparations of mammary glands from late-pregnant and lactating rats. The tissues showed extensive conversion of glucose into lactate in vitro, but not in vivo. Therefore aerobic lactate formation is not a normal feature of mammary tissue, but occurs in vitro as the result of some metabolic derangement.

Full text

PDF
273

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BURTON K. A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem J. 1956 Feb;62(2):315–323. doi: 10.1042/bj0620315. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Chatwin A. L., Linzell J. L., Setchell B. P. Cardiovascular changes during lactation in the rat. J Endocrinol. 1969 Jun;44(2):247–254. doi: 10.1677/joe.0.0440247. [DOI] [PubMed] [Google Scholar]
  3. Coore H. G., Field B. Properties of pyruvate dehydrogenase of rat mammary tissue and its changes during pregnancy, lactation and weaning. Biochem J. 1974 Jul;142(1):87–95. doi: 10.1042/bj1420087. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. FOLLEY S. J., FRENCH T. H. The intermediary metabolism of the mammary gland; respiration and acid production of mammary tissue during pregnancy, lactation and involution in the rat. Biochem J. 1949;45(3):270–275. doi: 10.1042/bj0450270. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hawkins R. A., Williamson D. H. Measurements of substrate uptake by mammary gland of the rat. Biochem J. 1972 Oct;129(5):1171–1173. doi: 10.1042/bj1291171. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Katz J., Wals P. A. Pentose cycle and reducing equivalents in rat mammary-gland slices. Biochem J. 1972 Jul;128(4):879–899. doi: 10.1042/bj1280879. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Krebs H. A. The Pasteur effect and the relations between respiration and fermentation. Essays Biochem. 1972;8:1–34. [PubMed] [Google Scholar]
  8. Kuhn N. J., Lowenstein J. M. Lactogenesis in the rat. Changes in metabolic parameters at parturition. Biochem J. 1967 Dec;105(3):995–1002. doi: 10.1042/bj1050995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. McAllister A., Allison S. P., Randle P. J. Effects of dichloroacetate on the metabolism of glucose, pyruvate, acetate, 3-hydroxybutyrate and palmitate in rat diaphragm and heart muscle in vitro and on extraction of glucose, lactate, pyruvate and free fatty acids by dog heart in vivo. Biochem J. 1973 Aug;134(4):1067–1081. doi: 10.1042/bj1341067. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Moretti R. L., Abraham S. Effects of insulin on glucose metabolism by explants of mouse mammary gland maintained in organ culture. Biochim Biophys Acta. 1966 Aug 24;124(2):280–288. doi: 10.1016/0304-4165(66)90191-7. [DOI] [PubMed] [Google Scholar]
  11. Pitelka D. R., Kerkof P. R., Gagné H. T., Smith S., Abraham S. Characteristics of cells dissociated from mouse mammary glands. I. Method of separation and morphology of parenchymal cells from lactating glands. Exp Cell Res. 1969 Sep;57(1):43–62. doi: 10.1016/0014-4827(69)90365-6. [DOI] [PubMed] [Google Scholar]
  12. REES E. D., EVERSOLE A. RAT MAMMARY GLAND METABOLISM RELATIVE TO EPITHELIAL AND CONNECTIVE TISSUE CONTENT. Am J Physiol. 1964 Sep;207:595–600. doi: 10.1152/ajplegacy.1964.207.3.595. [DOI] [PubMed] [Google Scholar]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society

RESOURCES