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. 1975 Jan;146(1):277–279. doi: 10.1042/bj1460277

Hydroxypyruvate as a gluconeogenic substrate in rat hepatocytes.

D H Williamson, E V Ellington
PMCID: PMC1165298  PMID: 1147901

Abstract

At concentrations of 2mM and above hydroxypyruvate produced no glucose with isolated rat liver cells, although it was rapidly utilized. At a lower concentration of hydroxypyruvate or in the presence of substrates which generate reducing equivalents (ethanol or butyrate), appreciable amounts of glucose were formed from hydroxypyruvate. A possible explanation for this phenomenon is discussed.

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Selected References

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