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. 1975 Aug;150(2):259–262. doi: 10.1042/bj1500259

Drug induction and sex differences of renal glutathione S-transferases in the rat.

G Clifton, N Kaplowitz, J D Wallin, J Kuhlenkamp
PMCID: PMC1165733  PMID: 1180917

Abstract

Treatment of male rats with 3,4-benzopyrene, 3-methylcholanthrene and phenobarbital resulted in the induction of glutathione S-aryl- and S-aralkyl-transferase activities in kidney cytosol. Benzopyrene produced 77 and 44% increases in aryl and aralkyl activities respectively. Methylcholanthrene caused 73 and 86% increases in the retrospective activities, whereas phenobarbital treatment increased only aralkyl activity (51%). There was no effect on epoxide or alkyl glutathione S-transferase activities with these treatments. Differences were found between the specific activities of the four glutathione S-transferases in females and males, with the following female/male ratios: aryl 0.74; aralkyl 2.37; epoxide 1.52; alkyl 1.33. No changes in Km values were observed relative to drug induction or sex differences. Comparisons are made between the findings of this report and corresponding experiements with liver.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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