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. 1975 Sep;150(3):463–469. doi: 10.1042/bj1500463

Regulation of synthesis of ribosomal proteins during pyrimidine starvation in Escherichia coli.

B G Beatty, W W Mak, J T Wong
PMCID: PMC1165761  PMID: 1108874

Abstract

The synthesis of ribosomal proteins during pyrimidine starvation was investigated. A progressive turn-off of protein synthesis, with a decay half-time of about 5 min, was observed when Escherichia coli cells were starved of uridine. By means of double-labelling, the syntheses of different ribosomal proteins were shown to be turned off unequally during the starvation. Comparison of the turn-off patterns for some proteins and the known polycistronic organization of the structural genes for these proteins suggests that a major cause of the unequal turn-off was the degradation of mRNA molecules for the ribosomal proteins from the 5'-end toward the 3'-end.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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