Abstract
1. A porphyrinogenic drug, 3,5-diethoxycarbonyl-1,4-dihydrocollidine, caused a decrease in the proportion of single ("run off") ribosomes, and an increase in the number of polyribosomes, in the livers of treated animals. 2. No change could be detected in the distribution of amino acid incorporation among hepatic polyribosomes.
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Selected References
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- De Matteis F., Abbritti G., Gibbs A. H. Decreased liver activity of porphyrin-metal chelatase in hepatic porphyria caused by 3,5-diethoxycarbonyl-1,4-dihydrocollidine. Studies in rats and mice. Biochem J. 1973 Jul;134(3):717–727. doi: 10.1042/bj1340717. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Elder G. H., Gray C. H., Nicholson D. C. The porphyrias: a review. J Clin Pathol. 1972 Dec;25(12):1013–1033. doi: 10.1136/jcp.25.12.1013. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gayathri A. K., Padmanaban G. Biochemical effects of 3,5-diethoxycarbonyl-1,4-dihydrocollidine in mouse liver. Biochem Pharmacol. 1974 Oct 1;23(19):2713–2725. doi: 10.1016/0006-2952(74)90042-2. [DOI] [PubMed] [Google Scholar]
- Liu A. Y., Neuhaus O. W. Injury and plasma protein biosynthesis. II. Hepatic microsomal activity and polysomal organization. Biochim Biophys Acta. 1968 Aug 23;166(1):195–204. doi: 10.1016/0005-2787(68)90503-0. [DOI] [PubMed] [Google Scholar]
- Nawata H., Kato K. Ribonucleic acid synthesis in porphyric rat liver induced by 3,5-dicarbethoxy-1,4-dihydrocollidine. Biochem J. 1973 Sep;136(1):209–215. doi: 10.1042/bj1360209. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Norman M., Gamulin S., Clark K. The distribution of ribosomes between different functional states in livers of fed and starved mice. Biochem J. 1973 Jun;134(2):387–398. doi: 10.1042/bj1340387. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Webb T. E., Blobel G., Potter V. R. Polyribosomes in rat tissues. 3. The response of the polyribosome pattern of rat liver to physiologic stress. Cancer Res. 1966 Feb;26(2):253–257. [PubMed] [Google Scholar]