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. 1973 Oct;135(2):257–263. doi: 10.1042/bj1350257

Mechanism and stereochemistry of the 5-aminolaevulinate synthetase reaction*

Z Zaman 1, P M Jordan 1, M Akhtar 1
PMCID: PMC1165818  PMID: 4543543

Abstract

1. Two mechanisms for the biosynthesis of 5-aminolaevulinate from glycine and succinyl-CoA (3-carboxypropionyl-CoA) are considered. One of the mechanisms involves the retention of both the C-2 H atoms of glycine during the synthesis of 5-aminolaevulinate, whereas the other predicts the retention of only one of the C-2 H atoms of glycine. 2. Highly purified 5-aminolaevulinate synthetase from Rhodopseudomonas spheroides was used to show that the C-2 H atom of glycine with R configuration is specifically removed during the biosynthesis of 5-aminolaevulinate. 3. The mechanism of the condensation therefore differs from the analogous reaction of the biosynthesis of sphinganine from palmitoyl-CoA and serine, in which the C-2 H of serine is retained (Wiess, 1963).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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