Abstract
1. Pigeon liver `malic' enzyme [l-malate–NADP+ oxidoreductase (decarboxylating); EC 1.1.1.40] was shown to catalyse the reductase reaction: [Formula: see text] l-Malate was identified as the reaction product, and was formed in stoicheiometric amount. 2. In addition to oxaloacetate and pyruvate, a number of other α-oxo carboxylic acids were also reduced.
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Selected References
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- Cazzulo J. J., Massarini E. Inhibition of NADP-linked malic enzyme by glyoxylate. FEBS Lett. 1972 Apr 15;22(1):76–79. doi: 10.1016/0014-5793(72)80223-0. [DOI] [PubMed] [Google Scholar]
- Hsu R. Y., Lardy H. A. Pigeon liver malic enzyme. II. Isolation, crystallization, and some properties. J Biol Chem. 1967 Feb 10;242(3):520–526. [PubMed] [Google Scholar]
- Hsu R. Y., Lardy H. A. Pigeon liver malic enzyme. IV. Pyruvate reductase activity of the crystalline enzyme. Acta Biochim Pol. 1967;14(1):183–186. [PubMed] [Google Scholar]
- Hsu R. Y. Mechanism of pigeon liver malic enzyme. Formation of L-lactate from L-malate, and effects of modification of protein thiol groups on malic enzyme, oxalacetate, and pyruvate reductase activities. J Biol Chem. 1970 Dec 25;245(24):6675–6682. [PubMed] [Google Scholar]
- MEISTER A. Reduction of alpha gamma-diketo and alpha-keto acids catalyzed by muscle preparations and by crystalline lactic dehydrogenase. J Biol Chem. 1950 May;184(1):117–129. [PubMed] [Google Scholar]
- STICKLAND R. G. Some properties of the malic enzyme of pigeon liver. 1. Conversion of malate into pyruvate. Biochem J. 1959 Dec;73:646–654. doi: 10.1042/bj0730646. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tsai C. S., Tsai Y. H., Samad R. A. Cations in component reactions of 'malic' enzyme catalysis. Biochem J. 1971 Aug;124(1):193–197. doi: 10.1042/bj1240193. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zink M. W. Regulation of the two "malic" enzymes in Neurospora crassa. Can J Microbiol. 1972 May;18(5):611–617. doi: 10.1139/m72-097. [DOI] [PubMed] [Google Scholar]