Abstract
6-O-Alkyl-d-galactoses competitively inhibit the erythrocyte sugar-transport system when added to the outside of the cells, but not to the inside. n-Propyl β-d-glucopyranoside competitively inhibits the system on the inside of the cells, but not on the outside. A model for sugar transport is proposed.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- BOWYER F., WIDDAS W. F. The action of inhibitors on the facilitated hexose transfer system in erythrocytes. J Physiol. 1958 Apr 30;141(2):219–232. doi: 10.1113/jphysiol.1958.sp005969. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Baker G. F., Widdas W. F. The asymmetry of the facilitated transfer system for hexoses in human red cells and the simple kinetics of a two component model. J Physiol. 1973 May;231(1):143–165. doi: 10.1113/jphysiol.1973.sp010225. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Baker G. F., Widdas W. F. The permeation of human red cells by 4,6-O-ethylidene- -D-glucopyranose (ethylidene glucose). J Physiol. 1973 May;231(1):129–142. doi: 10.1113/jphysiol.1973.sp010224. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Barnett J. E., Holman G. D., Munday K. A. Structural requirements for binding to the sugar-transport system of the human erythrocyte. Biochem J. 1973 Feb;131(2):211–221. doi: 10.1042/bj1310211. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Edwards P. A. The inactivation by fluorodinitrobenzene of glucose transport across the human erythrocyte membrane. The effect of glucose inside or outside the cell. Biochim Biophys Acta. 1973 May 11;307(2):415–418. doi: 10.1016/0005-2736(73)90107-7. [DOI] [PubMed] [Google Scholar]
- Geck P. Eigenschaften eines asymmetrischen Carrier-Modells für den Zuckertrnasport am menschlichen Erythrozyten. Biochim Biophys Acta. 1971 Aug 13;241(2):462–472. doi: 10.1016/0005-2736(71)90045-9. [DOI] [PubMed] [Google Scholar]
- Kahlenberg A., Dolansky D. Structural requirements of D-glucose for its binding to isolated human erythrocyte membranes. Can J Biochem. 1972 Jun;50(6):638–643. doi: 10.1139/o72-088. [DOI] [PubMed] [Google Scholar]
- Karlish S. J., Lieb W. R., Ram D., Stein W. D. Kinetic parameters of glucose efflux from human red blood cells under zero-trans conditions. Biochim Biophys Acta. 1972 Jan 17;255(1):126–132. doi: 10.1016/0005-2736(72)90014-4. [DOI] [PubMed] [Google Scholar]
- Krupka R. M. Evidence for a carrier conformational change associated with sugar transport in erythrocytes. Biochemistry. 1971 Mar 30;10(7):1143–1148. doi: 10.1021/bi00783a007. [DOI] [PubMed] [Google Scholar]
- LeFevre P. G. A model for erythrocyte sugar transport based on substrate-conditioned "introversion" of binding sites. J Membr Biol. 1973 Jan 23;11(1):1–19. doi: 10.1007/BF01869810. [DOI] [PubMed] [Google Scholar]
- Levine M., Levine S., Jones M. N. The effect of temperature on the competitive inhibition of sorbose transfer in human erythrocytes by glucose. Biochim Biophys Acta. 1971 Feb 2;225(2):291–300. doi: 10.1016/0005-2736(71)90222-7. [DOI] [PubMed] [Google Scholar]
- Levine M., Stein W. D. The kinetic parameters of the monosaccharide transfer system of the human erythrocyte. Biochim Biophys Acta. 1966 Sep 26;127(1):179–193. doi: 10.1016/0304-4165(66)90488-0. [DOI] [PubMed] [Google Scholar]
- Lieb W. R., Stein W. D. Quantitative predictions of a noncarrier model for glucose transport across the human red cell membrane. Biophys J. 1970 Jul;10(7):585–609. doi: 10.1016/s0006-3495(70)86322-6. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Miller D. M. The kinetics of selective biological transport. IV. Assessment of three carrier systems using the erythrocyte-monosaccharide transport data. Biophys J. 1968 Nov;8(11):1339–1352. doi: 10.1016/S0006-3495(68)86560-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Naftalin R. J. A model for sugar transport across red cell membranes without carriers. Biochim Biophys Acta. 1970 Jul 7;211(1):65–78. doi: 10.1016/0005-2736(70)90124-0. [DOI] [PubMed] [Google Scholar]
- Vidaver G. A. Inhibition of parallel flux and augmentation of counter flux shown by transport models not involving a mobile carrier. J Theor Biol. 1966 Feb;10(2):301–306. doi: 10.1016/0022-5193(66)90128-7. [DOI] [PubMed] [Google Scholar]