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editorial
. 2024 Dec 19;19(12):e0316407. doi: 10.1371/journal.pone.0316407

Editorial Note: Olmesartan Potentiates the Anti-Angiogenic Effect of Sorafenib in Mice Bearing Ehrlich’s Ascites Carcinoma: Role of Angiotensin (1–7)

The PLOS ONE Editors
PMCID: PMC11658613  PMID: 39700204

Concerns have been raised about discrepancies in the methods and results between this article [1] and a related thesis by the first author [2]. In response, the first author stated that the discrepancies are due to errors in [2]. The first author also provided the underlying data for this article [S1–S9 Files] and additional information on the antibodies used in [1] (Table 1). The VEGFR2 antibody details were not clarified.

Table 1. Antibody details.

Antibody Description Source Catalogue number
IGF receptors Mouse monoclonal antibody against human IGF-1 receptor Thermo Fisher Scientific (Fremont, USA). Biocare Medical
CM 414 A, C
CD31 Mouse monoclonal antibody against human CD31 Thermo Fisher Scientific (Fremont, USA). #MS-353-R7

A member of the Editorial Board reviewed the concerns and authors’ responses, and was satisfied with the responses, but noted that hematoxylin & eosin (H&E) staining is mentioned in the Materials and Methods in [1] but is not shown.

Supporting information

S1 File. Individual-level quantitative data underlying the tumor weight results in [1].

(XLSX)

pone.0316407.s001.xlsx (22KB, xlsx)
S2 File. Individual-level quantitative data underlying the Serum VEGF results in [1].

(XLSX)

pone.0316407.s002.xlsx (22.7KB, xlsx)
S3 File. Individual-level quantitative data underlying the Serum IGF-I results in [1].

(XLSX)

pone.0316407.s003.xlsx (23.7KB, xlsx)
S4 File. Individual-level quantitative data underlying the VEGFR2 results in [1].

(XLSX)

pone.0316407.s004.xlsx (24.8KB, xlsx)
S5 File. Individual-level quantitative data underlying the IGF-IR results in [1].

(XLSX)

pone.0316407.s005.xlsx (23.4KB, xlsx)
S6 File. Individual-level quantitative data underlying the CD31 results in [1].

(XLSX)

pone.0316407.s006.xlsx (25.2KB, xlsx)
S7 File. Underlying images supporting the VEGFR results in [1].

(RAR)

pone.0316407.s007.rar (5.1MB, rar)
S8 File. Underlying images supporting the IGFR results in [1].

(RAR)

pone.0316407.s008.rar (5.1MB, rar)
S9 File. Underlying images supporting the CD31 results in [1].

(RAR)

References

  • 1.Abd-Alhaseeb MM, Zaitone SA, Abou-El-Ela SH, Moustafa YM (2014) Olmesartan Potentiates the Anti-Angiogenic Effect of Sorafenib in Mice Bearing Ehrlich’s Ascites Carcinoma: Role of Angiotensin (1–7). PLoS ONE 9(1): e85891. 10.1371/journal.pone.0085891 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 2.Abd-Alhaseeb El-Mahdy MM (2010) Anti-angiogenic effect of the AT1R blocker, Olmesartan, in addition to sorafenib in in-vivo and in-vitro models of cancer. PhD thesis, Suez Canal University [Google Scholar]

Associated Data

This section collects any data citations, data availability statements, or supplementary materials included in this article.

Supplementary Materials

S1 File. Individual-level quantitative data underlying the tumor weight results in [1].

(XLSX)

pone.0316407.s001.xlsx (22KB, xlsx)
S2 File. Individual-level quantitative data underlying the Serum VEGF results in [1].

(XLSX)

pone.0316407.s002.xlsx (22.7KB, xlsx)
S3 File. Individual-level quantitative data underlying the Serum IGF-I results in [1].

(XLSX)

pone.0316407.s003.xlsx (23.7KB, xlsx)
S4 File. Individual-level quantitative data underlying the VEGFR2 results in [1].

(XLSX)

pone.0316407.s004.xlsx (24.8KB, xlsx)
S5 File. Individual-level quantitative data underlying the IGF-IR results in [1].

(XLSX)

pone.0316407.s005.xlsx (23.4KB, xlsx)
S6 File. Individual-level quantitative data underlying the CD31 results in [1].

(XLSX)

pone.0316407.s006.xlsx (25.2KB, xlsx)
S7 File. Underlying images supporting the VEGFR results in [1].

(RAR)

pone.0316407.s007.rar (5.1MB, rar)
S8 File. Underlying images supporting the IGFR results in [1].

(RAR)

pone.0316407.s008.rar (5.1MB, rar)
S9 File. Underlying images supporting the CD31 results in [1].

(RAR)


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