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. 1973 Dec;136(4):1053–1058. doi: 10.1042/bj1361053

A model for the passage of the neurohypophysial hormones and their related proteins through the rat neurohypophysis

Graham D Burford *, Peter Clifford †, C W Jones *, Brian T Pickering *
PMCID: PMC1166056  PMID: 4786527

Abstract

The change in the radioactivity of vasopressin–neurophysin in the rat neurohypophysis after an intracisternal injection of [35S]cysteine was fitted to several mathematical models. The data fitted best a model in which there is a linear input of radioactive protein into one pool of the neurohypophysis, from which it is either released by an exponential process or transferred to a second pool from which it is released by a second exponential process with a rate constant much lower than the first. This model is compatible with the existence of a `readily releasable' pool first postulated by Sachs et al. (1967). Data for the change in radioactivity of vasopressin also gave a good fit in this model. Calculation of the rate constants suggested that the first pool represented about 2% of the total hormone.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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