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. 1974 Apr;139(1):169–181. doi: 10.1042/bj1390169

The amine oxidases of human placenta and pregnancy plasma

William G Bardsley 1, M James C Crabbe 1, Ian V Scott 1
PMCID: PMC1166264  PMID: 4219137

Abstract

1. The purification of monoamine oxidase and diamine oxidase from normal human term placental tissue is described. 2. The properties of these enzymes are reported and compared with the properties of unpurified human pregnancy plasma. 3. This comparison shows that the amine oxidase of pregnancy plasma has properties corresponding to purified placental diamine oxidase, suggesting a placental origin for the plasma enzyme system. 4. Detailed kinetic study of the purified placental diamine oxidase suggests that it has a Ping Pong sequence, a mechanism of action and rate-limiting step similar to the diamine oxidase of pig kidney. 5. It is suggested that the enzyme system is important in protecting the foeto-placental unit from excesses of biogenic amines.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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