Skip to main content
. 2024 Dec 4;27(12):111437. doi: 10.1016/j.isci.2024.111437

Figure 10.

Figure 10

SPARC partially reverses the function of miR-532-3p in vitro

(A) Cell proliferation was reversed with co-transfection of miR-532-3p mimics (50 nM) and SPARC (2 μg) on QBC939 cells after incubation with OXA (5 μmol/L) and 5-Fu (10 μmol/L).

(B) Similarly, cell apoptosis was reversed on QBC939 cells after incubation with OXA (5 μmol/L) and 5-Fu (10 μmol/L) for 48 h.

(C) Cell proliferation was reversed with co-transfection of miR-532-3p inhibitor (100 nM) and siRNA (100 nM) on FRH0201 cells after incubation with OXA (20 μmol/L) and 5-Fu (80 μmol/L).

(D) Cell apoptosis was reversed on FRH0201 cells after incubation with OXA (20 μmol/L) and 5-Fu (80 μmol/L) for 48 h. Data are represented as mean ± SD. n = 3, ∗∗∗p < 0.001, ns: no significance, SPARC secreted protein acidic and rich in cysteine, OXA oxaliplatin, 5-Fu 5-fluorouracil, siRNA small interfering RNA, NC negative control.