Skip to main content
. 2024 Dec 4;27(12):111437. doi: 10.1016/j.isci.2024.111437

Figure 8.

Figure 8

SPARC influences the IC50 values of OXA/5-Fu in vitro

(A–C) Successful transfection of SPARC plasmids on QBC939 cells and siRNA against SPARC on FRH cells.

(D and E) IC50 values of OXA (D) and 5-Fu (E) on QBC939 cells.

(F and G) IC50 values of OXA (F) and 5-Fu (G) on FRH0201 cells. Data are represented as mean ± SD. n = 3, ∗∗p < 0.01, ∗∗∗p < 0.001, SPARC secreted protein acidic and rich in cysteine, IC50 half inhibitory concentration, OXA oxaliplatin, 5-Fu 5-fluorouracil, siRNA small interfering RNA, NC negative control.