REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Mouse monoclonal anti-β-actin	Abcam	Cat#ab6276; RRID: AB_2223210
Rabbit monoclonal anti-SPARC	Abcam	Cat#ab207743; RRID: AB_2924283
Bacterial and virus strains
Lv-miR-532-3p	Genechem	N/A
Lv-sponge-miR-532-3p	Genechem	N/A
Biological samples
Bile samples	Peking university cancer hospital (China)	N/A
Chemicals, peptides, and recombinant proteins
Oxaliplatin	MedChemexpress	Cat#HY-17371
5-fluorouracil	MedChemexpress	Cat#HY-90006
Critical commercial assays
High-throughput sequencing of miRNAs and mRNAs	CloudSeq Biotech Inc	N/A
Lipofectamine RNAiMAX	Invitrogen	Cat#13778030
Lipofectamine 3000	Invitrogen	Cat#L3000001
MicroRNA Reverse Transcription Kit	EZBioscience	Cat#EZB-miRT3
PrimeScript™ RT Reagent Kit	Takara Bio USA	Cat#RR037A
bicinchoninic acid protein assay kit	Servicebio	Cat#G2026-200T
ECL Plus Western Blotting Detection Reagents	Solarbio	Cat#PE0010
Counting Kit-8 (CCK-8) kit	Solarbio	Cat#CA1210
Trizol reagent	Thermo Fisher	Cat#15596018CN
Deposited data
miRNA-seq count data	This paper	https://data.mendeley.com/datasets/6rx2k6xhjg/2
mRNA-seq count data	This paper	https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE280797
Experimental models: Cell lines
QBC939 cells	Qingqi (Shanghai) Biotechnology development Co., LTD	Cat#BFN60810642
FRH0201 cells	Otwo Biotech	Cat#HTX2093
293T cell line	Cell Bank of the Chinese Academy of Sciences	SCSP-502
Oligonucleotides
See Table S1 for sequences of miRNA mimics, inhibitor, and siRNA	N/A	N/A
See Table S2 for primer sequences in qPCR	N/A	N/A
Recombinant DNA
pcDNA3.1-secreted protein acidic and rich in cysteine (SPARC)	Genechem	N/A
control vector plasmids	Genechem	N/A
Software and algorithms
SPSS 20.0 software	IBM	https://www.ibm.com/support/pages/spss-statistics-20-available-download
GraphPad Prism 9	GraphPad Software	https://www.graphpad.com/scientific-software/prism/