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. 1986 Dec 1;5(12):3367–3372. doi: 10.1002/j.1460-2075.1986.tb04652.x

Regulatory sequences in the promoter of the Dictyostelium Actin 6 gene.

W Nellen, C Silan, U Saur, R A Firtel
PMCID: PMC1167335  PMID: 3816763

Abstract

The promoter region of the developmentally regulated Actin 6 gene of Dictyostelium has been dissected by a series of deletions. Functional analysis of the deletions in Dictyostelium transformants revealed two short regulatory sequences: a positive upstream element (PUE) between -599 and -572 which increases transcription by a factor of 10 but does not affect the developmental pattern of expression and an upstream activator sequence (UAS) between -249 and -215 which is essential for transcription and proper developmental regulation. The UAS partially coincides with a conserved sequence with dyad symmetry found upstream of several Dictyostelium actin genes (Romans and Firtel, 1985a).

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Selected References

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