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. 1981 Oct;133(Pt 3):359–370.

Metabolic turnover of collagen in the mouse molar periodontal ligament during tooth eruption.

K A Perera, C H Tonge
PMCID: PMC1167607  PMID: 7328043

Abstract

Metabolic turnover of collagen in the developing molar periodontal ligament was studied in 10, 12 and 16 days old mice by autoradiography after the administration of [3H]proline. Grain counts, in number per unit area, were made over three different zones (apical, middle and cervical) of the sections and activity time curves were drawn. Calculated regressions (log10 grain density V time) were fitted and analyses of variance to test the linearity of the regressions were carried out using the computer. Slopes +/- S.E. of the regressions, and half-lives were estimated. This study has demonstrated that collagen turnover occurred throughout the whole thickness of the ligament, from bone to cementum. Therefore, there was no evidence of a metabolically active 'intermediate plexus' in the periodontal ligament. However, the turnover rates in the apical zones of the three groups studied were significantly higher than those in the middle zones, which in turn were higher than those in the cervical zones, suggesting a differential rate of collagen turnover within the periodontal ligament. This whole sequence was significantly higher in the 12 days old compared with the 10 and 16 days old groups. Estimated half-lives confirmed this pattern of rate of collagen turnover. The molar periodontal ligament behaves and functions as a 'stimulated system' during the period 10 to 16 days, with a statistically significant rate of collagen turnover at the twelfth day, which is also the time of tooth eruption in the mouse. Thus, collagen turnover is an essential and accompanying process of tooth eruption.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson A. A. The protein matrixes of the teeth and periodontium in hamsters: a tritiated proline study. J Dent Res. 1967 Jan-Feb;46(1):67–67. doi: 10.1177/00220345670460014401. [DOI] [PubMed] [Google Scholar]
  2. Beertsen W. Tissue dynamics in the periodontal ligament of the mandibular incisor of the mouse: a preliminary report. Arch Oral Biol. 1973 Jan;18(1):61–66. doi: 10.1016/0003-9969(73)90020-4. [DOI] [PubMed] [Google Scholar]
  3. Carneiro J., de Moraes F. F. Radioautographic visualization of collagen metabolism in the periodontal tissues of the mouse. Arch Oral Biol. 1965 Nov-Dec;10(6):833–848. doi: 10.1016/0003-9969(65)90077-4. [DOI] [PubMed] [Google Scholar]
  4. Ciancio S. C., Neiders M. E., Hazen S. P. The principal fibers of the periodontal ligament. Periodontics. 1967 Mar-Apr;5(2):76–81. [PubMed] [Google Scholar]
  5. ECCLES J. D. THE DEVELOPMENT OF THE PERIODONTAL MEMBRANE IN THE RAT INCISOR. Arch Oral Biol. 1964 Mar-Apr;9:127–133. doi: 10.1016/0003-9969(64)90002-0. [DOI] [PubMed] [Google Scholar]
  6. Eccles J. D. The effects of reducing function and stopping eruption on the periodontium of the rat incisor. J Dent Res. 1965 Sep-Oct;44(5):860–868. doi: 10.1177/00220345650440051901. [DOI] [PubMed] [Google Scholar]
  7. Kameyama Y. An autoradiographic investigation of the developing rat periodontal membrane. Arch Oral Biol. 1973 Apr;18(4):473–480. doi: 10.1016/0003-9969(73)90067-8. [DOI] [PubMed] [Google Scholar]
  8. Magnusson B. Tissue changes during molar tooth eruption. Trans R Sch Dent Stockh Umea. 1968;13:1–122. [PubMed] [Google Scholar]
  9. Melcher A. H., Correia M. A. Remodelling of periodontal ligament in erupting molars of mature rats. J Periodontal Res. 1971;6(2):118–125. doi: 10.1111/j.1600-0765.1971.tb00598.x. [DOI] [PubMed] [Google Scholar]
  10. Melcher A. H. Remodelling of the periodontal ligament during eruption of the rat incisor. Arch Oral Biol. 1967 Dec;12(12):1649–1651. doi: 10.1016/0003-9969(67)90199-9. [DOI] [PubMed] [Google Scholar]
  11. Perera K. A., Tonge C. H. Fibroblast cell population kinetics in the mouse molar periodontal ligament and tooth eruption. J Anat. 1981 Sep;133(Pt 2):281–300. [PMC free article] [PubMed] [Google Scholar]
  12. Perera K. A., Tonge C. H. Fibroblast cell proliferation in the mouse molar periodontal ligament. J Anat. 1981 Aug;133(Pt 1):77–90. [PMC free article] [PubMed] [Google Scholar]
  13. SICHER H. Changing concepts of the supporting dental structures. Oral Surg Oral Med Oral Pathol. 1959 Jan;12(1):31–35. doi: 10.1016/0030-4220(59)90078-7. [DOI] [PubMed] [Google Scholar]
  14. Skougaard M. R., Bay I., Klinkhamer J. M. Correlation between gingivitis and orogranulocytic migratory rate. J Dent Res. 1969 Sep-Oct;48(5):716–718. doi: 10.1177/00220345690480051801. [DOI] [PubMed] [Google Scholar]
  15. Skougaard M. R., Frandsen A., Baker D. G. Collagen metabolism of skin and periodontal membrane in the squirrel monkey. Scand J Dent Res. 1970;78(5):374–377. doi: 10.1111/j.1600-0722.1970.tb02084.x. [DOI] [PubMed] [Google Scholar]
  16. ZWARYCH P. D., QUIGLEY M. B. THE INTERMEDIATE PLEXUS OF THE PERIODONTAL LIGAMENT: HISTORY AND FURTHER OBSERVATIONS. J Dent Res. 1965 Mar-Apr;44:383–391. doi: 10.1177/00220345650440021301. [DOI] [PubMed] [Google Scholar]

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