Abstract
The number and diameter of fibres in three different muscles from streptozotocin-diabetic rats were compared to the same muscles from animals of two, non-diabetic, control groups. The animals of the weight control group were fed a restricted food intake so that they grew at the same rate as the diabetic animals, whereas the other group received the stock diet ad libitum. Although body weight was the same for the diabetic and the weight control rats, the muscles weighed less in the diabetic animals. This was reflected in trends to fibres with smaller diameters and to lower fibre number in the diabetic animals. These differences between diabetic and control animals became more significant when the number and diameter of fibres were used to calculate total cross sectional area. There was no damage to the fibres when examined under the light microscope. It is concluded that streptozotocin-diabetes has an adverse effect on the number and diameter of fibres in skeletal muscles.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Armstrong R. B., Gollnick P. D., Ianuzzo C. D. Histochemical properties of skeletal muscle fibers in streptozotocin-diabetic rats. Cell Tissue Res. 1975 Oct 13;162(3):387–394. doi: 10.1007/BF00220185. [DOI] [PubMed] [Google Scholar]
- Armstrong R. B., Ianuzzo C. D. Compensatory hypertrophy of skeletal muscle fibers in streptozotocin-diabetic rats. Cell Tissue Res. 1977 Jul 11;181(2):255–266. doi: 10.1007/BF00219985. [DOI] [PubMed] [Google Scholar]
- Chao T. T., Ianuzzo C. D., Armstrong R. B., Albright J. T., Anapolle S. E. Ultrastructural alterations in skeletal muscle fibers of streptozotocin-diabetic rats. Cell Tissue Res. 1976 May 6;168(2):239–246. doi: 10.1007/BF00215880. [DOI] [PubMed] [Google Scholar]
- Dahlmann B., Schroeter C., Herbertz L., Reinauer H. Myofibrillar protein degradation and muscle proteinases in normal and diabetic rats. Biochem Med. 1979 Feb;21(1):33–39. doi: 10.1016/0006-2944(79)90052-8. [DOI] [PubMed] [Google Scholar]
- Donovan W. H., Sumi S. M. Diabetic amyotrophy--a more diffuse process than clinically suspected. Arch Phys Med Rehabil. 1976 Aug;57(8):397–403. [PubMed] [Google Scholar]
- Goldberg A. L. Influence of insulin and contractile activity on muscle size and protein balance. Diabetes. 1979 Jan;28 (Suppl 1):18–24. doi: 10.2337/diab.28.1.s18. [DOI] [PubMed] [Google Scholar]
- Jefferson L. S., Rannels D. E., Munger B. L., Morgan H. E. Insulin in the regulation of protein turnover in heart and skeletal muscle. Fed Proc. 1974 Apr;33(4):1098–1104. [PubMed] [Google Scholar]
- Layman D. K., Hegarty P. V., Swan P. B. Comparison of morphological and biochemical parameters of growth in rat skeletal muscles. J Anat. 1980 Jan;130(Pt 1):159–171. [PMC free article] [PubMed] [Google Scholar]
- Pain V. M., Garlick P. J. Effect of streptozotocin diabetes and insulin treatment on the rate of protein synthesis in tissues of the rat in vivo. J Biol Chem. 1974 Jul 25;249(14):4510–4514. [PubMed] [Google Scholar]
- Saltin B., Houston M., Nygaard E., Graham T., Wahren J. Muscle fiber characteristics in healthy men and patients with juvenile diabetes. Diabetes. 1979 Jan;28 (Suppl 1):93–99. doi: 10.2337/diab.28.1.s93. [DOI] [PubMed] [Google Scholar]
- Schmalbruch H., Kamieniecka Z. Fiber types in the human brachial biceps muscle. Exp Neurol. 1974 Aug;44(2):313–328. doi: 10.1016/0014-4886(74)90069-7. [DOI] [PubMed] [Google Scholar]
- Stearns S. B., Tepperman H. M., Tepperman J. Studies on the utilization and mobilization of lipid in skeletal muscles from streptozotocin-diabetic and control rats. J Lipid Res. 1979 Jul;20(5):654–662. [PubMed] [Google Scholar]