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. 1981 Sep;133(Pt 2):213–225.

A study of degeneration, scar formation and regeneration after section of the optic nerve in the frog, Rana pipiens.

T M Scott, J Foote
PMCID: PMC1167665  PMID: 6977520

Abstract

Degeneration, scar formation and regeneration have been studied after section of the optic nerve in the frog. In the normal optic nerve two types of macroglial cell were identified: astrocytes and oligodendroglia. Degeneration after injury proceeded rapidly in comparison with mammals but did not lead to the production of a dense scar. Before much scarring had developed, regenerating axons penetrated the lesioned area.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CLEMENTE C. D. REGENERATION IN THE VERTEBRATE CENTRAL NERVOUS SYSTEM. Int Rev Neurobiol. 1964;6:257–301. doi: 10.1016/s0074-7742(08)60771-0. [DOI] [PubMed] [Google Scholar]
  2. Canković J. G. Contribution to the study of regenerative-degenerative qualities of the fasciculi optici in mammals under experimental conditions. Acta Anat (Basel) 1968;70(1):117–123. [PubMed] [Google Scholar]
  3. Cook R. D., Wiśniewski H. M. The role of oligodendroglia and astroglia in Wallerian degeneration of the optic nerve. Brain Res. 1973 Oct 26;61:191–206. doi: 10.1016/0006-8993(73)90527-1. [DOI] [PubMed] [Google Scholar]
  4. FREEMAN L. W. Experimental observations upon axonal regeneration in the transected spinal cord of mammals. Clin Neurosurg. 1962;8:294–319. doi: 10.1093/neurosurgery/8.cn_suppl_1.294. [DOI] [PubMed] [Google Scholar]
  5. Field P. M., Coldham D. E., Raisman G. Synapse formation after injury in the adult rat brain: preferential reinnervation of denervated fimbrial sites by axons of the contralateral fimbria. Brain Res. 1980 May 5;189(1):103–113. doi: 10.1016/0006-8993(80)90010-4. [DOI] [PubMed] [Google Scholar]
  6. Field P. M. Synapse formation after injury in the adult rat brain: failure of fimbrial axons to reinnervate the bed nucleus of the stria terminalis. Brain Res. 1980 May 5;189(1):91–101. doi: 10.1016/0006-8993(80)90009-8. [DOI] [PubMed] [Google Scholar]
  7. Hirose G., Bass N. H. A quantitative histochemical study of early cellular events associated with destruction of myelinated axons in rat optic nerve. Exp Neurol. 1974 Jul;44(1):82–95. doi: 10.1016/0014-4886(74)90048-x. [DOI] [PubMed] [Google Scholar]
  8. Kao C. C., Chang L. W., Bloodworth J. M., Jr Axonal regeneration across transected mammalian spinal cords: an electron microscopic study of delayed microsurgical nerve grafting. Exp Neurol. 1977 Mar;54(3):591–615. doi: 10.1016/0014-4886(77)90259-x. [DOI] [PubMed] [Google Scholar]
  9. Kruger L., Maxwell D. S. Wallerian degeneration in the optic nerve of a reptile: an electron microscopic study. Am J Anat. 1969 Jul;125(3):247–269. doi: 10.1002/aja.1001250302. [DOI] [PubMed] [Google Scholar]
  10. LIU C. N., CHAMBERS W. W. Intraspinal sprouting of dorsal root axons; development of new collaterals and preterminals following partial denervation of the spinal cord in the cat. AMA Arch Neurol Psychiatry. 1958 Jan;79(1):46–61. [PubMed] [Google Scholar]
  11. Lin H., Ingram W. R. Axonal degeneration in the peripheral optic pathway of the cat. Exp Neurol. 1973 Mar-Apr;39(2):234–248. doi: 10.1016/0014-4886(73)90226-4. [DOI] [PubMed] [Google Scholar]
  12. Lund R. D., Lund J. S. Synaptic adjustment after deafferentation of the superior colliculus of the rat. Science. 1971 Feb 26;171(3973):804–807. doi: 10.1126/science.171.3973.804. [DOI] [PubMed] [Google Scholar]
  13. MATURANA H. R. The fine anatomy of the optic nerve of anurans--an electron microscope study. J Biophys Biochem Cytol. 1960 Feb;7:107–120. doi: 10.1083/jcb.7.1.107. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Marks A. F. Regenerative reconstruction of a tract in a rat's brain. Exp Neurol. 1972 Mar;34(3):455–464. doi: 10.1016/0014-4886(72)90041-6. [DOI] [PubMed] [Google Scholar]
  15. Murray M., Goldberger M. E. Restitution of function and collateral sprouting in the cat spinal cord: the partially hemisected animal. J Comp Neurol. 1974 Nov 1;158(1):19–36. doi: 10.1002/cne.901580103. [DOI] [PubMed] [Google Scholar]
  16. Murray M. Regeneration of retinal axons into the goldfish optic tectum. J Comp Neurol. 1976 Jul 15;168(2):175–195. doi: 10.1002/cne.901680202. [DOI] [PubMed] [Google Scholar]
  17. Raisman G. Neuronal plasticity in the septal nuclei of the adult rat. Brain Res. 1969 Jun;14(1):25–48. doi: 10.1016/0006-8993(69)90029-8. [DOI] [PubMed] [Google Scholar]
  18. Reier P. J. Penetration of grafted astrocytic scars by regenerating optic nerve axons in Xenopus tadpoles. Brain Res. 1979 Mar 23;164:61–68. doi: 10.1016/0006-8993(79)90006-4. [DOI] [PubMed] [Google Scholar]
  19. Reier P. J., Webster H. F. Regeneration and remyelination of Xenopus tadpole optic nerve fibres following transection or crush. J Neurocytol. 1974 Nov;3(5):591–618. doi: 10.1007/BF01097626. [DOI] [PubMed] [Google Scholar]
  20. Skoff R. P., Vaughn J. E. An autoradiographic study of cellular proliferation in degenerating rat optic nerve. J Comp Neurol. 1971 Feb;141(2):133–155. doi: 10.1002/cne.901410202. [DOI] [PubMed] [Google Scholar]
  21. Stensaas L. J., Feringa E. R. Axon regeneration across the site of injury in the optic nerve of the newt Triturus pyrrhogaster. Cell Tissue Res. 1977 Apr 29;179(4):501–516. doi: 10.1007/BF00219852. [DOI] [PubMed] [Google Scholar]
  22. Turner J. E., Singer M. The ultrastructure of regeneration in the severed newt optic nerve. J Exp Zool. 1974 Dec;190(3):249–268. doi: 10.1002/jez.1401900302. [DOI] [PubMed] [Google Scholar]
  23. WINDLE W. F. Regeneration of axons in the vertebrate central nervous system. Physiol Rev. 1956 Oct;36(4):427–440. doi: 10.1152/physrev.1956.36.4.427. [DOI] [PubMed] [Google Scholar]
  24. Wendell-Smith C. P., Blunt M. J., Baldwin F. The ultrastructural characterization of macroglial cell types. J Comp Neurol. 1966 Jun;127(2):219–240. doi: 10.1002/cne.901270207. [DOI] [PubMed] [Google Scholar]

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