Skip to main content
NCBI home page
Journal of Anatomy logoLink to Journal of Anatomy
. 1996 Dec;189(Pt 3):477–482.

The intestinal uptake of particles and the implications for drug and antigen delivery.

D T O'Hagan 1
PMCID: PMC1167686  PMID: 8982819

Abstract

A number of researchers from different scientific disciplines have independently described the uptake of a variety of particulates across the gastrointestinal tract in animal models. The reports of particle uptake are briefly reviewed and the alternative mechanisms and proposed sites of uptake are discussed. Following these observations, some researchers have exploited the phenomenon of particulate uptake by using microparticles and nanoparticles as oral delivery systems for active agents, such as drugs and vaccines. The potential use of particulate carrier systems as drug and vaccine delivery systems is also briefly discussed.

Full text

PDF
477

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Challacombe S. J., Rahman D., Jeffery H., Davis S. S., O'Hagan D. T. Enhanced secretory IgA and systemic IgG antibody responses after oral immunization with biodegradable microparticles containing antigen. Immunology. 1992 May;76(1):164–168. [PMC free article] [PubMed] [Google Scholar]
  2. Damgé C., Michel C., Aprahamian M., Couvreur P. New approach for oral administration of insulin with polyalkylcyanoacrylate nanocapsules as drug carrier. Diabetes. 1988 Feb;37(2):246–251. doi: 10.2337/diab.37.2.246. [DOI] [PubMed] [Google Scholar]
  3. Ebel J. P. A method for quantifying particle absorption from the small intestine of the mouse. Pharm Res. 1990 Aug;7(8):848–851. doi: 10.1023/a:1015964916486. [DOI] [PubMed] [Google Scholar]
  4. Eyles J., Alpar O., Field W. N., Lewis D. A., Keswick M. The transfer of polystyrene microspheres from the gastrointestinal tract to the circulation after oral administration in the rat. J Pharm Pharmacol. 1995 Jul;47(7):561–565. doi: 10.1111/j.2042-7158.1995.tb06714.x. [DOI] [PubMed] [Google Scholar]
  5. Freedman B. J. Persorption of raw starch: a cause of senile dementia? Med Hypotheses. 1991 Jun;35(2):85–87. doi: 10.1016/0306-9877(91)90028-w. [DOI] [PubMed] [Google Scholar]
  6. Fukui H., Murakami M., Yoshikawa H., Takada K., Muranishi S. Studies on the promoting effect of lipid-surfactant mixed micelles (MM) on intestinal absorption of colloidal particles. Dependence on particle size and administration site. J Pharmacobiodyn. 1987 Jun;10(6):236–242. doi: 10.1248/bpb1978.10.236. [DOI] [PubMed] [Google Scholar]
  7. Hillery A. M., Jani P. U., Florence A. T. Comparative, quantitative study of lymphoid and non-lymphoid uptake of 60 nm polystyrene particles. J Drug Target. 1994;2(2):151–156. doi: 10.3109/10611869409015904. [DOI] [PubMed] [Google Scholar]
  8. Hodges G. M., Carr E. A., Hazzard R. A., Carr K. E. Uptake and translocation of microparticles in small intestine. Morphology and quantification of particle distribution. Dig Dis Sci. 1995 May;40(5):967–975. doi: 10.1007/BF02064184. [DOI] [PubMed] [Google Scholar]
  9. Jani P., Halbert G. W., Langridge J., Florence A. T. Nanoparticle uptake by the rat gastrointestinal mucosa: quantitation and particle size dependency. J Pharm Pharmacol. 1990 Dec;42(12):821–826. doi: 10.1111/j.2042-7158.1990.tb07033.x. [DOI] [PubMed] [Google Scholar]
  10. Jepson M. A., Simmons N. L., O'Hagan D. T., Hirst B. H. Comparison of poly(DL-lactide-co-glycolide) and polystyrene microsphere targeting to intestinal M cells. J Drug Target. 1993;1(3):245–249. doi: 10.3109/10611869308996082. [DOI] [PubMed] [Google Scholar]
  11. Jones D. H., McBride B. W., Thornton C., O'Hagan D. T., Robinson A., Farrar G. H. Orally administered microencapsulated Bordetella pertussis fimbriae protect mice from B. pertussis respiratory infection. Infect Immun. 1996 Feb;64(2):489–494. doi: 10.1128/iai.64.2.489-494.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. LeFevre M. E., Boccio A. M., Joel D. D. Intestinal uptake of fluorescent microspheres in young and aged mice. Proc Soc Exp Biol Med. 1989 Jan;190(1):23–27. doi: 10.3181/00379727-190-42825. [DOI] [PubMed] [Google Scholar]
  13. LeFevre M. E., Hancock D. C., Joel D. D. Intestinal barrier to large particulates in mice. J Toxicol Environ Health. 1980 Jul;6(4):691–704. doi: 10.1080/15287398009529888. [DOI] [PubMed] [Google Scholar]
  14. Maincent P., Le Verge R., Sado P., Couvreur P., Devissaguet J. P. Disposition kinetics and oral bioavailability of vincamine-loaded polyalkyl cyanoacrylate nanoparticles. J Pharm Sci. 1986 Oct;75(10):955–958. doi: 10.1002/jps.2600751009. [DOI] [PubMed] [Google Scholar]
  15. Maloy K. J., Donachie A. M., O'Hagan D. T., Mowat A. M. Induction of mucosal and systemic immune responses by immunization with ovalbumin entrapped in poly(lactide-co-glycolide) microparticles. Immunology. 1994 Apr;81(4):661–667. [PMC free article] [PubMed] [Google Scholar]
  16. O'Hagan D. T., Palin K. J., Davis S. S. Poly(butyl-2-cyanoacrylate) particles as adjuvants for oral immunization. Vaccine. 1989 Jun;7(3):213–216. doi: 10.1016/0264-410x(89)90231-4. [DOI] [PubMed] [Google Scholar]
  17. Pappo J., Ermak T. H., Steger H. J. Monoclonal antibody-directed targeting of fluorescent polystyrene microspheres to Peyer's patch M cells. Immunology. 1991 Jul;73(3):277–280. [PMC free article] [PubMed] [Google Scholar]
  18. Pappo J., Ermak T. H. Uptake and translocation of fluorescent latex particles by rabbit Peyer's patch follicle epithelium: a quantitative model for M cell uptake. Clin Exp Immunol. 1989 Apr;76(1):144–148. [PMC free article] [PubMed] [Google Scholar]
  19. Porta C., James P. S., Phillips A. D., Savidge T. C., Smith M. W., Cremaschi D. Confocal analysis of fluorescent bead uptake by mouse Peyer's patch follicle-associated M cells. Exp Physiol. 1992 Nov;77(6):929–932. doi: 10.1113/expphysiol.1992.sp003662. [DOI] [PubMed] [Google Scholar]
  20. Rubas W., Banerjea A. C., Gallati H., Speiser P. P., Joklik W. K. Incorporation of the reovirus M cell attachment protein into small unilamellar vesicles: incorporation efficiency and binding capability to L929 cells in vitro. J Microencapsul. 1990 Jul-Sep;7(3):385–395. doi: 10.3109/02652049009021848. [DOI] [PubMed] [Google Scholar]
  21. SANDERS E., ASHWORTH C. T. A study of particulate intestinal absorption and hepatocellular uptake. Use of polystyrene latex particles. Exp Cell Res. 1961 Jan;22:137–145. doi: 10.1016/0014-4827(61)90092-1. [DOI] [PubMed] [Google Scholar]
  22. Simon L., Shine G., Dayan A. D. Effect of animal age on the uptake of large particulates across the epithelium of the rat small intestine. Int J Exp Pathol. 1994 Oct;75(5):369–373. [PMC free article] [PubMed] [Google Scholar]
  23. Urbanski S. J., Arsenault A. L., Green F. H., Haber G. Pigment resembling atmospheric dust in Peyer's patches. Mod Pathol. 1989 May;2(3):222–226. [PubMed] [Google Scholar]
  24. Volkheimer G. Persorption of particles: physiology and pharmacology. Adv Pharmacol Chemother. 1977;14:163–187. doi: 10.1016/s1054-3589(08)60188-x. [DOI] [PubMed] [Google Scholar]
  25. Wells C. L., Maddaus M. A., Erlandsen S. L., Simmons R. L. Evidence for the phagocytic transport of intestinal particles in dogs and rats. Infect Immun. 1988 Jan;56(1):278–282. doi: 10.1128/iai.56.1.278-282.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Anatomy are provided here courtesy of Anatomical Society of Great Britain and Ireland

RESOURCES