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. 1974 Jun;140(3):363–368. doi: 10.1042/bj1400363

Hepatic drug hydroxylation and lipid peroxidation in riboflavin-deficient rats*

J M Patel 1, N R Galdhar 1, S S Pawar 1,†
PMCID: PMC1168012  PMID: 4374935

Abstract

The effect of riboflavin deficiency and phenobarbital pretreatment on drug hydroxylation and lipid peroxidation was investigated. A significant decrease in aniline and acetanilide hydroxylation as well as NADPH-linked and ascorbate-induced lipid peroxidation was observed during 4- and 7-week riboflavin deficiency in both adult male and adult female rats. The drug-hydroxylation and lipid-peroxidation activities were further lowered with the increase in riboflavin deficiency. The phenobarbital pretreatment induced aniline and acetanilide hydroxylase activity even in riboflavin-deficient animals. Drug hydroxylation inhibits lipid peroxidation in both deficient and normal rats. The administration of riboflavin was followed by a significant increase in drug hydroxylation and lipid peroxidation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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