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. 1974 Aug;141(2):517–526. doi: 10.1042/bj1410517

The structure and composition of cartilage keratan sulphate

John J Hopwood 1,*, H Clem Robinson 1
PMCID: PMC1168106  PMID: 4281656

Abstract

Keratan sulphate was isolated from bovine intervertebral disc and bovine nasal septum after hydrolysis with proteinases and treatment with dilute alkali. Each preparation was found to contain, per keratan sulphate chain: (a) 1 residue of mannose; (b) 3 residues of N-acetylneuraminic acid (2 residues after alkali treatment); (c) 1 residue of N-acetylgalactosamine (lost after alkali treatment); (d) 1 residue or less of fucose. N-Acetyl-neuraminic acid residues were at non-reducing termini and were bonded to keratan sulphate through galactose residues. Evidence is presented for two different types of linkage between skeletal keratan sulphate and protein. Consideration of molecular parameters and compositions leads to a proposed structure for keratan sulphate–protein as found in skeletal proteoglycans.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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