Abstract
Although the relative incorporation of incorrect nucleotide (dCTP or dGTP) into poly(dA-dT)·poly(dA-dT) by partially purified 3–4S DNA polymerase from normal or leukaemic human cells was four to five times higher than that by the 6–7S DNA polymerase, no significant differences in the infidelity of these polymerases between normal and leukaemic cells were noted.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Baril E. F., Jenkins M. D., Brown O. E., Laszlo J., Morris H. P. DNA polymerases I and II in regenerating rat liver and Morris hepatomas. Cancer Res. 1973 Jun;33(6):1187–1193. [PubMed] [Google Scholar]
- Han T. Studies of correlation of lymphocyte response to phytohemagglutinin with the clinical and immunologic status in chronic lymphocytic leukemia. Cancer. 1973 Feb;31(2):280–285. doi: 10.1002/1097-0142(197302)31:2<280::aid-cncr2820310202>3.0.co;2-o. [DOI] [PubMed] [Google Scholar]
- McCaffrey R., Smoler D. F., Baltimore D. Terminal deoxynucleotidyl transferase in a case of childhood acute lymphoblastic leukemia. Proc Natl Acad Sci U S A. 1973 Feb;70(2):521–525. doi: 10.1073/pnas.70.2.521. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sahai Srivastava B. I., Minowada J. Terminal deoxynucleotidyl transferase activity in a cell line (molt-4) derived from the peripheral blood of a patient with acute lymphoblastic leukemia. Biochem Biophys Res Commun. 1973 Apr 2;51(3):529–535. doi: 10.1016/0006-291x(73)91346-6. [DOI] [PubMed] [Google Scholar]
- Springgate C. F., Loeb L. A. Mutagenic DNA polymerase in human leukemic cells. Proc Natl Acad Sci U S A. 1973 Jan;70(1):245–249. doi: 10.1073/pnas.70.1.245. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Srivastava B. I. Deoxynucleotide-polymerizing enzymes in normal and malignant human cells. Cancer Res. 1974 May;34(5):1015–1026. [PubMed] [Google Scholar]