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. 1974 Sep;141(3):715–719. doi: 10.1042/bj1410715

Phosphonomethyl analogues of phosphate ester glycolytic intermediates

Henry B F Dixon 1, Michael J Sparkes 1
PMCID: PMC1168176  PMID: 4377103

Abstract

Analogues of dihydroxyacetone phosphate and of 3-phosphoglycerate were made in which the phosphate group, –O–PO3H2, is replaced by the phosphonomethyl group, –CH2–PO3H2. The analogue of dihydroxyacetone phosphate is a substrate for aldolase and glycerol 1-phosphate dehydrogenase (Stribling, 1974), but not for triose phosphate isomerase. The analogue of 3-phosphoglycerate oxidizes NADH under the combined action of 3-phosphoglycerate kinase and glyceraldehyde 3-phosphate dehydrogenase if ATP is added. Thus four out of the five glycolytic enzymes tested handle the phosphonomethyl compounds like the natural phosphates.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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