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. 1974 Sep;141(3):729–732. doi: 10.1042/bj1410729

Dehydrogenation of a phosphonate substrate analogue by glycerol 3-phosphate dehydrogenase

Paul R Adams 1, Roger Harrison 1, Thomas D Inch 2
PMCID: PMC1168179  PMID: 4463960

Abstract

S-(+)-3,4-Dihydroxybutylphosphonic acid, an isosteric analogue of sn-glycerol 3-phosphate, was synthesized stereospecifically and shown to be an effective substrate for rabbit muscle glycerol 3-phosphate dehydrogenase (sn-glycerol 3-phosphate–NAD+ oxidoreductase, EC 1.1.1.8). Non-isosteric phosphonate analogues of sn-glycerol 3-phosphate showed neither substrate nor inhibitory activity with the enzyme.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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