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. 1974 Sep;141(3):919–921. doi: 10.1042/bj1410919

X-ray fibre diffraction of cartilage proteoglycan aggregates containing hyaluronic acid (Short Communication)

E D T Atkins *, T E Hardingham †, D H Isaac *, H Muir †
PMCID: PMC1168199  PMID: 4282584

Abstract

Ordered conformations of proteoglycan–hyaluronic acid aggregates in the intercellular matrix in cartilage were observed by X-ray diffraction. The sodium salt form of three samples, (a) aggregated proteoglycan, (b) disaggregated proteoglycan and (c) reconstituted disaggregated proteoglycan, give essentially similar X-ray fibre-type diffraction photographs. The patterns correlate with the chondroitin 4-sulphate component and can be interpreted as twofold helical conformations, similar to that observed previously for the free acid form of chondroitin 4-sulphate (Isaac & Atkins, 1973). The information takes us one step nearer the situation found in cartilage in vivo.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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