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. 1974 Nov;144(2):397–402. doi: 10.1042/bj1440397

The effect of adrenocorticotrophin on protein degradation in rat adrenal gland and liver

Jacob A Canick 1,*, Dorothy B Villee 1
PMCID: PMC1168508  PMID: 4376961

Abstract

The rate of adrenal protein degradation appears to be slower in rats to which ACTH (adrenocorticotrophin) has been chronically administered. As measured by the exponential decay of radioactively labelled adrenal protein in vivo, the mean half-lives of total protein and of mitochondrial, microsomal and 18000g-supernatant protein were significantly longer in ACTH-treated animals. Experiments in which either [3H]leucine or NaH14CO3 was used to label proteins showed that of the fractions studied, the effect on mitochondrial protein degradation was most pronounced. The half-lives of the same subcellular fractions in rat liver were not affected by ACTH. The possibility that the results might have been caused by changes in radioisotope reutilization and pool size is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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