Abstract
Background:
There are limited therapeutic options in cases of failed reperfusion (modified thrombolysis in cerebral infarction [mTICI] score < 2b) after stent-retriever and/or aspiration based endovascular treatment (EVT) for acute ischemic stroke. Despite the absence of data supporting its use, rescue therapy (balloon angioplasty and/or stent implantation) is often utilized in such cases. Studies are limited to large vessel occlusions, while the outcomes and complications after rescue therapy in medium/distal vessel occlusions (MDVOs) have not been reported. This study aims to report the outcomes of rescue therapy in MDVO stroke patients.
Methods:
We performed an analysis of the “Blood pressure and Antiplatelet medication management after reScue angioplasty after failed Endovascular treatment in Large and distal vessel occlusions with probable IntraCranial Atherosclerotic Disease” (BASEL ICAD) retrospective registry. All MDVO stroke patients were included in the analysis.
Results:
Out of the 718 registry patients, 87 (12.1%) presented with an MDVO. Fifty-six patients (64.4%) showed an occlusion of the M2 segment of the middle cerebral artery. Rescue stenting was performed in 78 patients (89.7%) while balloon angioplasty alone was performed in 9 patients (10.3%). Successful reperfusion (mTICI score ⩾ 2b) was achieved in 73 (83.9%) patients after rescue therapy. Symptomatic intracranial hemorrhage (sICH) occurred in 8 patients (9.2%) and post-treatment stent occlusion in 12 patients (13.8%). Ninety days mortality was 20.7%. Twenty-eight patients (32.2%) achieved functional independence at 90 days (modified Rankin Scale 0–2).
Conclusion:
Rescue therapy with stenting and/or balloon angioplasty in patients undergoing EVT for isolated MDVO with suspected underlying intracranial atherosclerotic disease is an effective reperfusion strategy but is associated with complications and poor functional outcomes.
Keywords: Acute ischemic strokes, endovascular treatment, rescue stenting, intracranial atherosclerotic disease
Graphical abstract.
Introduction
Acute ischemic stroke (AIS) is a major contributor to mortality and disability, ranking third in terms of loss of quality-adjusted life years.1,2 For patients experiencing AIS due to a large vessel occlusion (LVO), endovascular treatment (EVT) has emerged as a standard treatment. 3 Over recent years and due to growing confidence with the procedure, EVT is often also extended to patients with medium/distal vessel occlusions (MDVOs), constituting 20%–40% of all AIS cases.4–7 Rapid and complete reperfusion achieved after EVT remains the primary predictor of positive outcomes. 8 Failed reperfusion (mTICI score < 2b) occurs in 10%–20% of cases, primarily due to underlying intracranial atherosclerotic disease (ICAD), which results in vessel stenosis or in-situ thrombosis leading to instant re-occlusion.9,10 It is often observed that after initial successful reperfusion, the artery reoccludes within the time span of minutes. Failure to achieve reperfusion is strongly associated with worse clinical outcomes, with rates of severe disability and death surpassing 70%. 11 There is no consensus on the best approach to handle failed reperfusion after EVT. 12
Rescue therapy with intracranial stenting or angioplasty has emerged as a potential treatment in such cases. Often, AIS from ICAD is caused by thrombosis from an activated atherosclerotic plaque. Thus, even with conventional removal of the thrombus from the occluded site, an activated plaque remains, and re-occlusion can occur. The local recurring thrombus can be potentially treated with the implantation of a stent or with balloon angioplasty alone.13,14 (Figure 1) However, this approach has not been evaluated in a large cohort of MDVOs with failed reperfusion. Furthermore, EVT in MDVO is currently under investigation in multiple randomized controlled trials and a matter of debate. 15
Figure 1.
Rescue stenting paradigm of an ICAD related occlusion in the M2 Segment of the MCA.
In this study we report the outcomes of patients undergoing rescue therapy during the EVT for the treatment of AIS due to MDVO.
Methods
We performed a retrospective analysis of the “Blood pressure and Antiplatelet medication management after reScue angioplasty after failed Endovascular treatment in Large and distal vessel occlusions with probable IntraCranial Atherosclerotic Disease” (BASEL ICAD) retrospective registry. Data were obtained from 32 EVT centers. Adult patients (Age ⩾ 18 years) were included in the BASEL ICAD registry if they underwent rescue therapy for the treatment of an LVO or MDVO between January 1st, 2019, and December 31st, 2023. Data from participating centers were curated by reviewing patient charts and procedure notes from the electronic medical records. This registry was approved by the applicable ethics committee (BASEC ID 2024-00904) with a waiver of consent.
For the current analysis only patients who had an isolated primary MDVO were included. We defined MDVO as an occlusion of the co- or non-dominant M2, the M3 or M4 segment of the middle cerebral artery (MCA), the A1, A2 or A3 segment of the anterior cerebral artery (ACA) or the P1, P2 or P3 segment of the posterior cerebral artery (PCA).
The primary clinical outcome was the modified Rankin Scale (mRS) at 90 days, while the primary procedural outcome was the rate of successful reperfusion (defined as a modified thrombolysis in cerebral infarction [mTICI] score of ⩾ 2b) at the end of the procedure. Secondary outcomes of interest included the National Institute of Health Stroke Scale (NIHSS) at 24 h, symptomatic intracranial hemorrhage (sICH) at 24 h scored with the Heidelberg Bleeding Classification, post-treatment stent occlusion (within 24 h and after day 7) and procedural complications. (Table 1) In addition, we performed a matching of MDVO with LVO patients from the BASEL-ICAD registry with ratio 1:2 using age, NIHSS at admission, pre-stroke mRS, intravenous thrombolysis (IVT), and stenting (vs balloon angioplasty alone) as matching variables. (Supplemental Table 2).
Table 1.
Patient characteristics and outcomes.
| Characteristics and outcomes | Overall | M2 | M3/M4, ACA, PCA | Missing (%) |
|---|---|---|---|---|
| Number | 87 | 56 | 31 | |
| Age | 71.6 (12.8) | 70.1 (13.6) | 74.2 (11.1) | 0.0 |
| Sex | 0.0 | |||
| Female | 36 (41.4) | 28 (50.0) | 8 (25.8) | |
| Male | 51 (58.6) | 28 (50.0) | 23 (74.2) | |
| Race | 12.6 | |||
| African American | 8 (10.5) | 7 (14.9) | 1 (3.4) | |
| Asian | 5 (6.6) | 4 (8.5) | 1 (3.4) | |
| White | 63 (82.9) | 36 (76.6) | 27 (93.1) | |
| Missing | 11 (12.6) | 9 (16.1) | 2 (6.5) | |
| Hypertension | 66 (75.9) | 44 (78.6) | 22 (71.0) | 2.3 |
| Dyslipidemia | 29 (33.3) | 17 (30.4) | 12 (38.7) | 18.4 |
| Diabetes mellitus | 20 (23.0) | 15 (26.8) | 5 (16.1) | 2.3 |
| Coronary artery occlusive disease | 12 (13.8) | 8 (14.3) | 4 (12.9) | 2.3 |
| Current or past smoking | 20 (23.0) | 16 (28.6) | 4 (12.9) | 3.4 |
| Atrial fibrillation | 9 (10.3) | 6 (10.7) | 3 (9.7) | 2.3 |
| History of stroke or TIA | 21 (24.1) | 14 (25.0) | 7 (22.6) | 2.3 |
| Pre-stroke mRS | 1.1 | |||
| 0 | 51 (58.6) | 33 (58.9) | 18 (58.1) | |
| 1 | 15 (17.2) | 11 (19.6) | 4 (12.9) | |
| 2 | 9 (10.3) | 6 (10.7) | 3 (9.7) | |
| 3 | 9 (10.3) | 4 (7.1) | 5 (16.1) | |
| 4 | 2 (2.3) | 1 (1.8) | 1 (3.2) | |
| Missing | 1 (1.1) | 1 (1.8) | 0 (0.0) | |
| Previous anticoagulation use | 7 (8.0) | 6 (10.7) | 1 (3.2) | 10.3 |
| Previous antiplatelet use | 9.2 | |||
| No | 59 (67.8) | 37 (66.1) | 22 (71.0) | |
| Single | 18 (20.7) | 11 (19.6) | 7 (22.6) | |
| Double | 2 (2.3) | 2 (3.6) | 0 (0.0) | |
| Missing | 8 (9.2) | 6 (10.7) | 2 (6.5) | |
| NIHSS admission | 9.0 [5.5, 14.5] | 10.0 [5.8, 14.2] | 8.0 [5.5, 14.5] | 0.0 |
| IVT | 24 (27.6) | 10 (17.9) | 14 (45.2) | 0.0 |
| Time onset to groin puncture (min) | 428.0 [204.0, 770.5] | 450.0 [212.5, 735.8] | 428.0 [203.0, 780.0] | 13.8 |
| Occluded vessel | 0.0 | |||
| A1/A2 | 7 (8.0) | 0 (0.0) | 7 (22.6) | |
| A3/A4 | 2 (2.3) | 0 (0.0) | 2 (6.5) | |
| M2 | 56 (64.4) | 56 (100.0) | 0 (0.0) | |
| M3/M4 | 1 (1.1) | 0 (0.0) | 1 (3.2) | |
| P1 | 17 (19.5) | 0 (0.0) | 17 (54.8) | |
| P2/P3 | 4 (4.6) | 0 (0.0) | 4 (12.9) | |
| Occlusion side | 2.3 | |||
| Left | 54 (62.1) | 35 (62.5) | 19 (61.3) | |
| Right | 31 (35.6) | 21 (37.5) | 10 (32.3) | |
| Missing | 2 (2.3) | 0 (0.0) | 2 (6.5) | |
| Etiology rescue stenting | 9.2 | |||
| ICAD | 65 (74.7) | 41 (73.2) | 24 (77.4) | |
| Dissection | 9 (10.3) | 6 (10.7) | 3 (9.7) | |
| Hard thrombus | 5 (5.7) | 3 (5.4) | 2 (6.5) | |
| Missing | 8 (9.2) | 6 (10.7) | 2 (6.5) | |
| Outcomes | ||||
| mRS 90 days | 10.3 | |||
| 0 | 8 (9.2) | 7 (12.5) | 1 (3.2) | |
| 1 | 11 (12.6) | 9 (16.1) | 2 (6.5) | |
| 2 | 9 (10.3) | 7 (12.5) | 2 (6.5) | |
| 3 | 14 (16.1) | 12 (21.4) | 2 (6.5) | |
| 4 | 14 (16.1) | 8 (14.3) | 6 (19.4) | |
| 5 | 4 (4.6) | 3 (5.4) | 1 (3.2) | |
| 6 | 18 (20.7) | 7 (12.5) | 11 (35.5) | |
| Missing | 9 (10.3) | 3 (5.4) | 6 (19.4) | |
| Functional independence at 90 days | 28 (32.2) | 23 (41.1) | 5 (16.1) | 10.3 |
| sICH | 8 (9.2) | 4 (7.1) | 4 (12.9) | 4.6 |
| NIHSS 24 h | 9.0 [4.0, 17.0] | 8.0 [4.0, 15.5] | 13.0 [4.0, 18.0] | 11.5 |
| Death | 18 (20.7) | 7 (12.5) | 11 (35.5) | 10.3 |
Results
Eighty-seven (12.1%) out of 718 BASEL ICAD registry patients had an MDVO. Seventy-eight (89.7%) underwent intracranial stenting, and nine (10.3%) angioplasty alone. The mean age was 71.6 years (±12.8) and 41.4% were female. Seventy-five patients (86.1%) had a pre-stroke mRS ⩽ 2 (51 of whom were mRS 0) and 11 (12.6%) > 2 (pre-stroke mRS was missing in one patient). The median admission NIHSS was 9 (Interquartile-Range [IQR] 5.5–14.5). Twenty-four patients (27.6%) received IVT. Median time of onset to groin puncture was 428 [IQR 204–770.5] minutes and median time of onset to recanalization was 508 min [IQR 308–800]. The most prevalent occlusion location was the M2 segment (56 patients, 64.4%). Other occlusion locations were the A1/A2 (7 patients, 8%), A3/A4 (2 patients, 2.3%), M3/M4 (1 patients, 1.1%), P1 (17 patients, 19.5%) and the P2/P3 segments (4 patients, 4.6%). (see Table 1 for baseline characteristics).
The mRS at 90 days was 0 in 8 cases (9.2%), 1 in 11 cases (12.6%), 2 in 9 cases (10.3%), 3 in 14 cases (16.1%), 4 in 14 cases (16.1%), 5 in 4 cases (4.6%), 6 in 18 cases (20.7%). We had 9 missing values. (Figure 2). Twenty-eight patients (32.2%) achieved a good functional outcome (defined as mRS 0–2) at 90 days. Median NIHSS at 24 h was 9 [IQR 4–17]. The highest mTICI score achieved prior to rescue therapy was 2a or lower in 48 patients (55.1%). The AIS etiology was deemed from the treating physician to be ICAD in 74.7% of the patients (n = 65). After rescue therapy mTICI ⩾ 2b was achieved in 73 (83.9%) patients, while 49 (56.3%) had mTICI ⩾ 2c. Rescue therapy was performed after a median of 2 (IQR 1–3) EVT passes. (see Table 2 for intervention characteristics). The most used stents were the CREDO® stent (Acandis, Pforzheim, Germany) in 27 patients, the Neuroform Atlas (Stryker, Kalamazoo, US) in 9 patients and the Acclino® stent (Acandis, Pforzheim, Germany) in 8 patients. Eighty-three (94.3%) patients received at least one peri-procedural antiplatelet medication: A single agent in 41 (47.1%), two agents in 33 (37.9%) and three agents in 9 (10.3%). (Supplemental Table 1). Efficacy and safety outcomes were not different between patients receiving IVT or no IVT.
Figure 2.
Distribution of the modified rankin scale (mRS) at 90 days in different distal vessel locations.
Table 2.
Intervention.
| Characteristics | Overall | M2 | M3/M4, ACA, PCA | Missing (%) |
|---|---|---|---|---|
| Number | 87 | 56 | 31 | |
| Anesthesia | 6.9 | |||
| General | 42 (48.3) | 25 (44.6) | 17 (54.8) | |
| Sedation | 39 (44.8) | 26 (46.4) | 13 (41.9) | |
| Missing | 6 (6.9) | 5 (8.9) | 1 (3.2) | |
| Access site | 6.9 | |||
| Femoral | 75 (86.2) | 49 (87.5) | 26 (83.9) | |
| Radial | 6 (6.9) | 2 (3.6) | 4 (12.9) | |
| Missing | 6 (6.9) | 5 (8.9) | 1 (3.2) | |
| Highest mTICI achieved prior to rescue therapy | 6.9 | |||
| 0 | 27 (31.0) | 20 (35.7) | 7 (22.6) | |
| 1 | 13 (14.9) | 8 (14.3) | 5 (16.1) | |
| 2a | 8 (9.2) | 4 (7.1) | 4 (12.9) | |
| 2b | 16 (18.4) | 9 (16.1) | 7 (22.6) | |
| 2c | 8 (9.2) | 6 (10.7) | 2 (6.5) | |
| 3 | 9 (10.3) | 5 (8.9) | 4 (12.9) | |
| Missing | 6 (6.9) | 4 (7.1) | 2 (6.5) | |
| mTICI after rescue therapy | 1.1 | |||
| 0 | 9 (10.3) | 5 (8.9) | 4 (12.9) | |
| 1 | 2 (2.3) | 1 (1.8) | 1 (3.2) | |
| 2a | 2 (2.3) | 1 (1.8) | 1 (3.2) | |
| 2b | 24 (27.6) | 16 (28.6) | 8 (25.8) | |
| 2c | 15 (17.2) | 9 (16.1) | 6 (19.4) | |
| 3 | 34 (39.1) | 24 (42.9) | 10 (32.3) | |
| Missing | 1 (1.1) | 0 (0.0) | 1 (3.2) | |
| Number of passes | 2.0 [1.0, 3.0] | 2.0 [1.0, 4.0] | 2.0 [2.0, 3.0] | 2.3 |
| Stenting | 78 (89.7) | 49 (87.5) | 29 (93.5) | 0.0 |
| Balloon angioplasty | 0.0 | |||
| No | 32 (36.8) | 23 (41.1) | 9 (29.0) | |
| Prestent | 35 (40.2) | 22 (39.3) | 13 (41.9) | |
| Poststent | 8 (9.2) | 2 (3.6) | 6 (19.4) | |
| Both | 3 (3.4) | 2 (3.6) | 1 (3.2) | |
| Alone | 9 (10.3) | 7 (12.5) | 2 (6.5) | |
| Time onset to recanalization (min) | 508.0 [308.0, 800.0] | 475.5 [321.5, 763.5] | 515.0 [270.0, 830.0] | 20.7 |
| Complications | 0.0 | |||
| No | 65 (74.7) | 41 (73.2) | 24 (77.4) | |
| SAH/vessel perforation | 11 (12.6) | 8 (14.3) | 3 (9.7) | |
| Dissection | 3 (3.4) | 2 (3.6) | 1 (3.2) | |
| Femoral/retroperitoneal hematoma | 3 (3.4) | 2 (3.6) | 1 (3.2) | |
| Other | 5 (5.7) | 3 (5.4) | 2 (6.5) | |
| Post-treatment stent occlusion | 12 (13.8) | 3 (5.4) | 9 (29.0) | 9.2 |
| Timing post-treatment stent occlusion | 89.7 | |||
| Within 24h | 7 (8.0) | 3 (5.4) | 4 (12.9) | |
| After day 7 | 1 (1.1) | 1 (3.2) | ||
| Missing/Not applicable | 79 (90.9) | 53 (94.6) | 26 (83.9) | |
| Periprocedural antiplatelets | 82 (94.3) | 51 (91.1) | 31 (100.0) | 0.0 |
| Number of periprocedural antiplatelets | 4.6 | |||
| 1 | 41 (47.1) | 25 (44.6) | 16 (51.6) | |
| 2 | 33 (37.9) | 19 (33.9) | 14 (45.2) | |
| 3 | 9 (10.3) | 8 (14.3) | 1 (3.2) | |
| Missing/Not applicable | 4 (4.6) | 4 (7.1) | 0 (0.0) | |
| Postprocedural antiplatelets | 81 (93.1) | 52 (92.9) | 29 (93.5) | 1.1 |
| Number of periprocedural antiplatelets | 5.7 | |||
| 1 | 14 (16.1) | 9 (16.1) | 5 (16.1) | |
| 2 | 68 (78.2) | 44 (78.6) | 24 (77.4) | |
| Missing/Not applicable | 5 (5.7) | 3 (5.4) | 2 (6.5) |
In 11 cases (12.6%) intraprocedural subarachnoid hemorrhage (SAH) or vessel perforation occurred. Post- treatment stent occlusion was reported in 12 (13.8%) patients and 8 patients (9.2%) had sICH. The risk of occlusion was higher in patients with postinterventional treatment with a single antiplatelet agent. The 90 day mortality rate was 20.7%. In the matched comparison with the LVO patients form the BASEL-ICAD registry, no significant differences were found. (Supplemental Table 2).
Discussion
The use of EVT is increasingly common in MDVO patients based on extrapolation of strong evidence in the treatment of LVO. This extrapolation extends to the potential use of rescue therapy in such patients. This is, to the best of our knowledge, the first study of rescue therapy in a large cohort of MDVO AIS patients. While it must be taken into considerations that comparisons between studies are to be interpreted with caution due to possible unidentified factors, it appears that outcomes in MDVO patients requiring intracranial stenting or angioplasty are worse compared to the overall population of MDVO patients undergoing EVT.16–18
Good functional outcome was achieved in 32.2% of the patients in the current study. Other studies examining EVT for MDVO patients (with or without angioplasty) have consistently reported higher rates of good functional outcome.16,19,20 In the INTERRSeCT/PRoveIT study the rate of mRS 0–2 was 67.4%. 16 The analysis further indicated that excellent outcome (mRS 0–1) was associated with successful early reperfusion. In the HERMES meta-analysis on M2 patients, the rate of good functional outcome was 58.2% in patients undergoing EVT. 20
This is despite, the fact that these patients presented with a more severe stroke than those in the current report, and successful reperfusion rates were lower in the HERMES meta-analysis (59.2% in HERMES vs 84.8% in the current report).
Rates of sICH were similar between our study and the INTERRSeCT/PRoveIT registry, while in the HERMES meta-analysis, 0% of sICH was reported. Mortality at 90 days was higher in our study (20.7%) compared to 8.9% in the INTERSECT/PROACT registry and 11.9% in the HERMES meta-analysis.
We hypothesize that the difference in good outcomes seen in EVT for MDVO with rescue therapy are due to one or more of the following: The fact that in our study only MDVOs were included, with possible technical and safety considerations arising from the small vessel size. The overall higher number of passes (since we include a cohort of failed thrombectomies), a higher rate of ischemic or hemorrhagic complications after rescue therapy compared to conventional EVT, and the need for antiplatelet medication to prevent vessel reocclusion. Even with such medication, stent-reocclusion occurred in 13.8% of patients.
Limitations
The limitations of this study are similar to all retrospective studies and mainly stem from the uncontrolled inclusion of patients (i.e. selection bias). A further limitation is the considerable variability in the antiplatelet treatment regimens and their unknown impact on patient outcome. Finally, because no core lab was available, radiological and clinical results were self-adjudicated. The sample size is limited. The most common occlusion site was the non-dominant M2-segment of the middle cerebral artery. The other locations are underrepresented. However, given that we could analyze a large number of patients for a relatively rare procedure, and given the multicenter nature of the registry, this study may meaningfully impact future trials of rescue therapy for MDVO.
Conclusion
Rescue therapy with stenting and/or balloon angioplasty in patients undergoing EVT for isolated MDVO with suspected underlying ICAD is an effective reperfusion strategy but is associated with complications and poor functional outcomes.
Supplemental Material
Supplemental material, sj-docx-1-eso-10.1177_23969873241311152 for Rescue therapy after failed thrombectomy in medium/distal vessel occlusions: A retrospective analysis of an international, multi-center registry by Aikaterini Anastasiou, Alex Brehm, Tomas Dobrocky, Adnan Mujanovic, Marta de Dios Lascuevas, Tomas Carmona Fuentes, Alfonso López-Frías López-Jurado, Blanca Hidalgo Valverde, Ansgar Berlis, Christoph J. Maurer, Thanh N Nguyen, Mohamad Abdalkader, Piers Klein, Guillaume Thevoz, Patrik Michel, Marius Kaschner, Daniel Weiss, Andrea M. Alexandre, Alessandro Pedicelli, Paolo Machi, Gianmarco Bernava, Shuntaro Kuwahara, Kazutaka Uchida, Jason Wenderoth, Anirudh Joshi, Grzegorz Karwacki, Lehel-Barna Lakatos, Agostino Tessitore, Sergio Lucio Vinci, Amedeo Cervo, Claudia Rollo, Ferdinand Hui, Aaisha Siddiqua Mozumder, Daniele Giuseppe Romano, Gianmarco Flora, Nitin Goyal, Vivek Batra, Violiza Inoa, Christophe Cognard, Matúš Hoferica, Riitta Rautio, Daniel Kaiser, Hanna Alph, Julian Clarke, Nick Hug, Alma Koch, Victor Schulze-Zachau, Nikki Rommers, Mira Katan and Marios-Nikos Psychogios in European Stroke Journal
Acknowledgments
We thank the BASEL ICAD Collaborators for their contribution to this project.
We thank Mr. Eleftherious Remoundos for help with preparation of Figures 1 and 2
Footnotes
Abbreviations and Acronyms: AIS Acute ischemic strokes
ACA anterior cerebral artery
EVT Endovascular Treatment
ICAD intracranial atherosclerotic disease
IVT intravenous thrombolysis
LVO large vessel occlusion
MCA middle cerebral artery
MDVO medium distal vessel occlusions
mRS modified Rankin Scale
mTICI modified treatment in cerebral infarction
NIHSS National Institutes of Health Stroke Scale
PCA posterior cerebral artery
sICH symptomatic intracranial hemorrhage
The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Victor Schulze-Zachau: discloses speaker fees from Medtronic Inc. (money paid to institution). V.S.-Z. is recipient of research grants from Basel University, Bangerter-Rhyner- Stiftung Basel and Freiwillige Akademische Gesellschaft Basel.
Thanh N Nguyen: discloses Associate Editor of Stroke; advisory board of Aruna Bio, Brainomix.
Kazutaka Uchida: reports lecturer’s fees from Daiichi Sankyo, Bristol-Myers Squibb, Stryker, and Medtronic.
Marios-Nikos Psychogios : discloses unrestricted grants from Swiss National Science Foundation (SNF), Bangerter-Rhyner Stiftung, Stryker Neurovascular Inc., Phenox GmbH, Medtronic Inc., Rapid Medical Inc., and Penumbra Inc for the DISTAL trial, grant for SPINNERS trial from Siemens Healthineers AG (money paid to institution) and the following speaker fees: Stryker Neurovascular Inc., Medtronic Inc., Penumbra Inc., Acandis GmbH, Phenox GmbH, Rapid Medical Inc. and Siemens Healthineers AG (money paid to institution).
Other authors declare that there is no conflict of interest.
Funding: The author(s) received no financial support for the research, authorship, and/or publication of this article.
Ethical approval: Approved by the applicable ethics committee (Business Administration System for Ethics Committees, BASEC ID 2024-00904) with a waiver of consent. The hospital of Bern and Geneva must edit and resend their Data Transfer Agreement document.
Informed consent: Not applicable.
Trial registration: Not applicable
Guarantor: M.-N.P.
Contributorship: A.A., A.B. and M.-N.P. researched literature and conceived the study.
N.R. was involved in protocol development and statistical analysis. A.A. created the cohort, contacted the collaborators and wrote the first draft of the manuscript. All authors reviewed and edited the manuscript and approved the final version of the manuscript.
ORCID iDs: Aikaterini Anastasiou 
https://orcid.org/0000-0002-5405-4237
Alex Brehm
https://orcid.org/0000-0002-1630-6210
Adnan Mujanovic
https://orcid.org/0000-0002-6839-7134
Thanh N Nguyen
https://orcid.org/0000-0002-2810-1685
Piers Klein
https://orcid.org/0000-0001-7468-137X
Andrea M. Alexandre
https://orcid.org/0000-0002-8080-3916
Agostino Tessitore
https://orcid.org/0000-0002-6163-4328
Christophe Cognard
https://orcid.org/0000-0003-4287-2627
Supplemental material: Supplemental material for this article is available online.
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Supplementary Materials
Supplemental material, sj-docx-1-eso-10.1177_23969873241311152 for Rescue therapy after failed thrombectomy in medium/distal vessel occlusions: A retrospective analysis of an international, multi-center registry by Aikaterini Anastasiou, Alex Brehm, Tomas Dobrocky, Adnan Mujanovic, Marta de Dios Lascuevas, Tomas Carmona Fuentes, Alfonso López-Frías López-Jurado, Blanca Hidalgo Valverde, Ansgar Berlis, Christoph J. Maurer, Thanh N Nguyen, Mohamad Abdalkader, Piers Klein, Guillaume Thevoz, Patrik Michel, Marius Kaschner, Daniel Weiss, Andrea M. Alexandre, Alessandro Pedicelli, Paolo Machi, Gianmarco Bernava, Shuntaro Kuwahara, Kazutaka Uchida, Jason Wenderoth, Anirudh Joshi, Grzegorz Karwacki, Lehel-Barna Lakatos, Agostino Tessitore, Sergio Lucio Vinci, Amedeo Cervo, Claudia Rollo, Ferdinand Hui, Aaisha Siddiqua Mozumder, Daniele Giuseppe Romano, Gianmarco Flora, Nitin Goyal, Vivek Batra, Violiza Inoa, Christophe Cognard, Matúš Hoferica, Riitta Rautio, Daniel Kaiser, Hanna Alph, Julian Clarke, Nick Hug, Alma Koch, Victor Schulze-Zachau, Nikki Rommers, Mira Katan and Marios-Nikos Psychogios in European Stroke Journal