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. 1999 Jan 15;18(2):320–329. doi: 10.1093/emboj/18.2.320

G1 cyclins block the Ime1 pathway to make mitosis and meiosis incompatible in budding yeast.

N Colomina 1, E Garí 1, C Gallego 1, E Herrero 1, M Aldea 1
PMCID: PMC1171127  PMID: 9889189

Abstract

Diploid yeast cells switch from mitosis to meiosis when starved of essential nutrients. While G1 cyclins play a key role in initiating the mitotic cell cycle, entry into meiosis depends on Ime1, a transcriptional activator regulated by both nutritional and cell-type signals. We show here that G1 cyclins downregulate IME1 transcription and prevent the accumulation of the Ime1 protein within the nucleus, which results in repression of early-meiotic gene expression. As G1-cyclin deficient cells do not require nutrient starvation to undergo meiosis, G1 cyclin would exert its role by transmitting essential nutritional signals to Ime1 function. The existence of a negative cross-talk mechanism between mitosis and meiosis may help explain why these two developmental options are incompatible in budding yeast.

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Selected References

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