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. 1976 Jan 15;154(1):171–178. doi: 10.1042/bj1540171

Inhibition of protein synthesis in reticulocyte lysates by trichodermin.

C J Carter, M Cannon, K E Smith
PMCID: PMC1172689  PMID: 1275906

Abstract

1. The effect of trichodermin as an inhibitor of eukaryotic protein synthesis was studied in a reticulocyte cell-free system. 2. Trichodermin at a concentration of 25 mug/ml inhibits total protein synthesis instantaneously and stabilizes polyribosome profiles. Conversely, at a concentration of 0.25 mug/ml the drug inhibits total protein synthesis by only 70-75% and allows 30-35% breakdown of the polyribosomes in the system. These effects were compared with those produced by two other drugs (pactamycin and anisomycin) examined under conditions identical with those used for trichodermin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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