Abstract
Rat brain contains 3-hydroxy-3-methylglutaryl-CoA reductase activity, but this enzyme is far more active in 7-day-old brain than in adult brain. This difference may partly explain why cholesterol biosynthesis is more rapid in growing than in adult rat brain.
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Selected References
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- Dobbing J. Vulnerable periods of brain development. In: lipids, malnutrition & the developing brain. Ciba Found Symp. 1971:9–29. [PubMed] [Google Scholar]
- Gregory K. W., Smith C. Z., Booth R. Diurnal variations in rat liver 3-hydroxy-3-methylglutaryl-Coenzyme A reductase activity in relation to feeding. Biochem J. 1972 Dec;130(4):1163–1165. doi: 10.1042/bj1301163. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kandutsch A. A., Saucier S. E. Regulation of sterol synthesis in developing brains of normal and jimpy mice. Arch Biochem Biophys. 1969 Dec;135(1):201–208. doi: 10.1016/0003-9861(69)90531-1. [DOI] [PubMed] [Google Scholar]
- LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
- McMILLAN P. J., DOUGLAS G. W., MORTENSEN R. A. Incorporation of C14 of acetate-1-C14 and pyruvate-2-C14 into brain cholesterol in the intact rat. Proc Soc Exp Biol Med. 1957 Dec;96(3):738–740. doi: 10.3181/00379727-96-23593. [DOI] [PubMed] [Google Scholar]