Abstract
Angiotensin III is formed from des-Asp1 -angiotensin I by angiotensin-converting enzyme. The Km (11 muM) of the reaction is one-third of that for the conversion of angiotensin I into angiotensin II. As suggested by the Km values, bradykinin, peptide BPP9a and angiotensins II and III are better inhibitors of the formation of angiotensin II than of the formation of angiotensin III.
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Selected References
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- Bravo E. L., Khosla M. C., Bumpus F. M. Action of (1-des(aspartic acid), 8-isoleucine) angiotensin II upon the pressor and steroidogenic activity of angiotensin II. J Clin Endocrinol Metab. 1975 Mar;40(3):530–533. doi: 10.1210/jcem-40-3-530. [DOI] [PubMed] [Google Scholar]
- Campbell W. B., Brooks S. N., Pettinger W. A. Angiotensin II- and angiotensin 3-induced aldosterone release vivo in the rat. Science. 1974 May 31;184(4140):994–996. doi: 10.1126/science.184.4140.994. [DOI] [PubMed] [Google Scholar]
- Cheung H. S., Cushman D. W. A soluble aspartate aminopeptidase from dog kidney. Biochim Biophys Acta. 1971 Jul 21;242(1):190–193. doi: 10.1016/0005-2744(71)90098-2. [DOI] [PubMed] [Google Scholar]
- Chiu A. T., Peach M. J. Inhibition of induced aldosterone biosynthesis with a specific antagonist of angiotensin II. Proc Natl Acad Sci U S A. 1974 Feb;71(2):341–344. doi: 10.1073/pnas.71.2.341. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cushman D. W., Cheung H. S. Concentrations of angiotensin-converting enzyme in tissues of the rat. Biochim Biophys Acta. 1971 Oct;250(1):261–265. doi: 10.1016/0005-2744(71)90142-2. [DOI] [PubMed] [Google Scholar]
- Das M., Soffer R. L. Pulmonary angiotensin-converting enzyme. Structural and catalytic properties. J Biol Chem. 1975 Sep 10;250(17):6762–6768. [PubMed] [Google Scholar]
- Dorer F. E., Kahn J. R., Lentz K. E., Levine M., Skeggs L. T. Formation of angiotensin II from tetradecapeptide renin substrate by angiotensin-converting enzyme. Biochem Pharmacol. 1975 May 15;24(10):1137–1139. doi: 10.1016/0006-2952(75)90207-5. [DOI] [PubMed] [Google Scholar]
- Dorer F. E., Kahn J. R., Lentz K. E., Levine M., Skeggs L. T. Hydrolysis of bradykinin by angiotensin-converting enzyme. Circ Res. 1974 Jun;34(6):824–827. doi: 10.1161/01.res.34.6.824. [DOI] [PubMed] [Google Scholar]
- Dorer F. E., Kahn J. R., Lentz K. E., Levine M., Skeggs L. T. Purification and properties of angiotensin-converting enzyme from hog lung. Circ Res. 1972 Sep;31(3):356–366. doi: 10.1161/01.res.31.3.356. [DOI] [PubMed] [Google Scholar]
- Dorer F., Ryan J. W., Stewart J. M. Hydrolysis of bradykinin and its higher homologues by angiotensin-converting enzyme. Biochem J. 1974 Sep;141(3):915–917. doi: 10.1042/bj1410915. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nagatsu I., Nagatsu T., Yamamoto T., Glenner G. G., Mehl J. W. Purification of aminopeptidase A in human serum and degradation of angiotensin II by the purified enzyme. Biochim Biophys Acta. 1970 Feb 11;198(2):255–270. doi: 10.1016/0005-2744(70)90058-6. [DOI] [PubMed] [Google Scholar]
- Pals D. T., Masucci F. D., Denning G. S., Jr, Sipos F., Fessler D. C. Role of the pressor action of angiotensin II in experimental hypertension. Circ Res. 1971 Dec;29(6):673–681. doi: 10.1161/01.res.29.6.673. [DOI] [PubMed] [Google Scholar]
- Pettinger W. A., Keeton K., Tanaka K. Radioimmunoassay and pharmacokinetics of saralasin in the rat and hypertensive patients. Clin Pharmacol Ther. 1975 Feb;17(2):146–158. doi: 10.1002/cpt1975172146. [DOI] [PubMed] [Google Scholar]
- Roth M., Weitzman A. F., Piquilloud Y. Converting enzyme content of different tissues of the rat. Experientia. 1969 Dec 15;25(12):1247–1247. doi: 10.1007/BF01897474. [DOI] [PubMed] [Google Scholar]
- Ryan J. W., Ryan U. S., Schultz D. R., Whitaker C., Chung A. Subcellular localization of pulmonary antiotensin-converting enzyme (kininase II). Biochem J. 1975 Feb;146(2):497–499. doi: 10.1042/bj1460497. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ryan J. W., Smith U., Niemeyer R. S. Angiotensin I: metabolism by plasma membrane of lung. Science. 1972 Apr 7;176(4030):64–66. doi: 10.1126/science.176.4030.64. [DOI] [PubMed] [Google Scholar]
- Ryan J. W., Stewart J. M., Leary W. P., Ledingham J. G. Metabolism of angiotensin I in the pulmonary circulation. Biochem J. 1970 Nov;120(1):221–223. doi: 10.1042/bj1200221. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SKEGGS L. T., Jr, KAHN J. R., SHUMWAY N. P. The preparation and function of the hypertensin-converting enzyme. J Exp Med. 1956 Mar 1;103(3):295–299. doi: 10.1084/jem.103.3.295. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tominaga M., Stewart J. M. Synthesis and properties of new bradykinin potentiating peptides. J Med Chem. 1975 Feb;18(2):130–133. doi: 10.1021/jm00236a003. [DOI] [PubMed] [Google Scholar]
