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. 1976 Jun 1;155(3):709–712. doi: 10.1042/bj1550709

Modification of brain deoxyribonucleic acid base content with maturation in normal and malnourished rats.

N W Penn
PMCID: PMC1172897  PMID: 949331

Abstract

The mol percentage of 5-hydroxymethylcytosine is 2.2 times greater in the adult than in 2-day-old rat brain DNA. The concentration of 5-hydroxymethylcytosine falls in corresponding liver DNA preparations. This normal increase in brain 5-hydroxymethylcytosine is abolished in rats placed on an 8%-protein diet 5 days after birth.

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Selected References

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  1. CAMPBELL R. M., KOSTERLITZ H. W. The effects of growth and sex on the composition of the liver cells of the rat. J Endocrinol. 1950 Jan;6(3):308–318. doi: 10.1677/joe.0.0060308. [DOI] [PubMed] [Google Scholar]
  2. CHARGAFF E., LIPSHITZ R., GREEN C., HODES M. E. The composition of the deoxyribonucleic acid of salmon sperm. J Biol Chem. 1951 Sep;192(1):223–230. [PubMed] [Google Scholar]
  3. Chase H. P., Lindsley W. F., Jr, O'Brien D. Undernutrition and cerebellar development. Nature. 1969 Feb 8;221(5180):554–555. doi: 10.1038/221554a0. [DOI] [PubMed] [Google Scholar]
  4. Chetsanga C. J., Boyd V., Peterson L., Rushlow K. Single-stranded regions in DNA of old mice. Nature. 1975 Jan 10;253(5487):130–131. doi: 10.1038/253130a0. [DOI] [PubMed] [Google Scholar]
  5. Fish I., Winick M. Effect of malnutrition on regional growth of the developing rat brain. Exp Neurol. 1969 Dec;25(4):534–540. doi: 10.1016/0014-4886(69)90096-x. [DOI] [PubMed] [Google Scholar]
  6. Gause G. G., Jr, Dolgilevich S. M., Fatkullina L. G., Mikhailov V. S. Heterogenous rapidly labeled DNA with the properties of replicating form in isolated rat liver mitochondria. Biochim Biophys Acta. 1973 Jun 23;312(2):179–191. doi: 10.1016/0005-2787(73)90363-8. [DOI] [PubMed] [Google Scholar]
  7. Herrmann R. L., Dowling L., Russell A. P., Bick M. D. Age-related changes in a spontaneously reassociating fraction of mouse DNA. Mech Ageing Dev. 1975 May-Aug;4(3-4):181–189. doi: 10.1016/0047-6374(75)90020-2. [DOI] [PubMed] [Google Scholar]
  8. Iwamura T. Nucleic acids in chloroplasts and metabolic DNA. Prog Nucleic Acid Res Mol Biol. 1966;5:133–155. doi: 10.1016/s0079-6603(08)60233-0. [DOI] [PubMed] [Google Scholar]
  9. Johnson R., Strehler B. L. Loss of genes coding for ribosomal RNA in ageing brain cells. Nature. 1972 Dec 15;240(5381):412–414. doi: 10.1038/240412a0. [DOI] [PubMed] [Google Scholar]
  10. Kimberlin R. H., Shirt D. B., Collis S. C. The turnover of isotopically labelled DNA in vivo in developing, adult and Scrapie-affected mouse brain. J Neurochem. 1974 Jul;23(1):241–248. doi: 10.1111/j.1471-4159.1974.tb06940.x. [DOI] [PubMed] [Google Scholar]
  11. Kurtz D. I., Sinex F. M. Age related differences in the association of brain DNA and nuclear protein. Biochim Biophys Acta. 1967;145(3):840–842. doi: 10.1016/0005-2787(67)90146-3. [DOI] [PubMed] [Google Scholar]
  12. LOEB M. R., COHEN S. S. The origin of purine and pyrimidine deoxyribose in T6r+ bacteriophage. J Biol Chem. 1959 Feb;234(2):364–369. [PubMed] [Google Scholar]
  13. Massie H. R., Baird M. B., Nicolosi R. J., Samis H. V. Changes in the structure of rat liver DNA in relation to age. Arch Biochem Biophys. 1972 Dec;153(2):736–741. doi: 10.1016/0003-9861(72)90392-x. [DOI] [PubMed] [Google Scholar]
  14. Penn N. W. Antagonism of barbiturate by DNA pyrimidines and allied compounds. Arch Int Pharmacodyn Ther. 1975 Nov;218(1):156–166. [PubMed] [Google Scholar]
  15. Penn N. W. Ethanol antagonism by 5-hydroxymethyl cellular compounds. Life Sci. 1975 Oct 10;17(7):1055–1061. doi: 10.1016/0024-3205(75)90324-0. [DOI] [PubMed] [Google Scholar]
  16. Penn N. W., Suwalski R., O'Riley C., Bojanowski K., Yura R. The presence of 5-hydroxymethylcytosine in animal deoxyribonucleic acid. Biochem J. 1972 Feb;126(4):781–790. doi: 10.1042/bj1260781. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Price G. B., Modak S. P., Makinodan T. Age-associated changes in the DNA of mouse tissue. Science. 1971 Mar 5;171(3974):917–920. doi: 10.1126/science.171.3974.917. [DOI] [PubMed] [Google Scholar]
  18. Samis H. V., Jr, Falzone J. A., Jr, Wulff V. J. H3-thymidine incorporation and mitotic activity in liver of rats of various ages. Gerontologia. 1966;12(2):79–88. doi: 10.1159/000211538. [DOI] [PubMed] [Google Scholar]
  19. WYATT G. R. The purine and pyrimidine composition of deoxypentose nucleic acids. Biochem J. 1951 May;48(5):584–590. doi: 10.1042/bj0480584. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. ZAMENHOF S., BURSZTYN H., RICH K., ZAMENHOF P. J. THE DETERMINATION OF DEOXYRIBONUCLEIC ACID AND OF CELL NUMBER IN BRAIN. J Neurochem. 1964 Jul;11:505–509. doi: 10.1111/j.1471-4159.1964.tb07499.x. [DOI] [PubMed] [Google Scholar]

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