Figure 1.

Angiotensin 1–7 (Ang 1–7) improves insulin resistance and glucose tolerance without affecting body weight, food intake, and epididymal white adipose tissue (eWAT) weight in dietary-induced obese mice. (a) Food intake, n = 4. (b) Body weight, n = 11–16. (c) Weight of eWAT, n = 11–15. (d) Levels of blood glucose during intraperitoneal glucose tolerance test (IPGTT), n = 10–15. (e) Levels of blood glucose during intraperitoneal insulin tolerance test (IPITT), n = 9–15. (f) Levels of blood glucose, serum insulin, and homeostasis model assessment of insulin resistance (HOMA-IR), with sample sizes of n = 11–15, n = 10–14, and n = 10–14, respectively. *p < 0.05, **p < 0.01. ^#p < 0.05 vs. NC. ^$p < 0.05 vs. HF. NC, mice fed a normal chow diet; HF, mice fed a high-fat diet alone; HFA, mice fed a high-fat diet and treated with Ang 1–7.